mdaB:Quickview: Difference between revisions
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!align=left | !align=left {{table_heading_style}} |Standard Name | ||
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''mdaB'' | ''mdaB'' | ||
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!align=left | !align=left {{table_heading_style}} |Gene Synonym(s) | ||
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''ECK3019, b3028, JW2996, mda66''<ref name='LIB:Riley_2006'/> | ''ECK3019, b3028, JW2996, mda66''<ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Desc. | ||
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EG12656<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | EG12656<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>; | ||
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FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric<ref name='LIB:EcoGene'/> | FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric<ref name='LIB:EcoGene'/> | ||
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!align=left | !align=left {{table_heading_style}} |Product Synonyms(s) | ||
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NADPH quinone reductase<ref name='LIB:Riley_2006'/>, B3028<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MdaB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | NADPH quinone reductase<ref name='LIB:Riley_2006'/>, B3028<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MdaB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ||
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!align=left | !align=left {{table_heading_style}} |Function from GO | ||
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!align=left | !align=left {{table_heading_style}} |Knock-Out Phenotype | ||
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!align=left {{table_heading_style}} |Regulation/Expression | |||
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transcription unit(s): [[:Category:Txn_unit:mdaB|mdaB]]<ref name='LIB:EcoCyc10.6'/> | transcription unit(s): [[:Category:Txn_unit:mdaB|mdaB]]<ref name='LIB:EcoCyc10.6'/> | ||
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!align=left | !align=left {{table_heading_style}} |Regulation/Activity | ||
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!align=left {{table_heading_style}} |Quick Links | |||
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[http://ecoliwiki.net/tools/display_dna.php?gene=mdaB&loc=MG1655:3170552..3171133,W3110:3171186..3171767,REL606:3106702..3107283,DH10B:3268297..3268878 DNA display] [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3268297&end=3268878&gene=mdaB&aa=msniliingakkfahsngqlndtltevadgtlrdlghdvrivradsdydvkaevqnflwadvviwqmpgwwmgapwtvkkyiddvfteghgtlyasdgrtrkdpskkygsgglvqgkkymlsltwnapmeaftekdqffhgvgvdgvylpfhkanqflgmeplptfiandvikmpdvpryteeyrkhlveifg Protein display] [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mdaB+AND+escherichia+coli Pubmed(mdaB)] [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=mdaB Textpresso(mdaB)] | |||
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Revision as of 23:44, 21 January 2010
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
See Help:Quickview for help with entering information in the Quickview table.
| Standard Name |
mdaB |
|---|---|
| Gene Synonym(s) |
ECK3019, b3028, JW2996, mda66[1] |
| Product Desc. |
Component of quinone reductase[3] FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric[4] |
| Product Synonyms(s) | |
| Function from GO | |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links | |
| edit table |
See Help:Quickview for help with entering information in the Quickview table.
Notes
MdaB overexpression results in resistance to cytotoxic drugs including adriamycin, etoposide and the tumoricidal agent DMP 840. Induced 25-fold by 2-methylene-4-butyrolactone and 2-methyl-1,4-naphthoquinone (menadione). mdaB is in an operon with ygiN. Reduces menadione to menadiol. May have some nitroreductase activity. Paradoxically also reported to be NADPH-specific.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.