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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''iaaA''  
''iaaA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK0818, b0828, JW0812, spt, ybiK''<ref name='LIB:Riley_2006'/>
''ECK0818, b0828, JW0812, spt, ybiK''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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IaaA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
IaaA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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isoAsp aminopeptidase, cleaves isoAsp-X dipeptides; Ntn hydrolase; glutathione utilization; weak L-asparaginase activity in vitro (EcAIII); precursor is cleaved into an alpha and beta subunit; heterotetrameric<ref name='LIB:EcoGene'/>
isoAsp aminopeptidase, cleaves isoAsp-X dipeptides; Ntn hydrolase; glutathione utilization; weak L-asparaginase activity in vitro (EcAIII); precursor is cleaved into an alpha and beta subunit; heterotetrameric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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L-asparaginase<ref name='LIB:Riley_2006'/>, B0828<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Spt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbiK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
L-asparaginase<ref name='LIB:Riley_2006'/>, B0828<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Spt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YbiK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
* GO:0009063 amino acid catabolic process ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0006530 asparagine catabolic process ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0016787 hydrolase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0004067 asparaginase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0004177 aminopeptidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IC])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:iaaA|iaaA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:iaaA|iaaA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=iaaA&loc=MG1655:865791..866756,W3110:866990..867955,DH10B:919719..920684,REL606:859120..860085 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=859120&end=860085&gene=iaaA&aa=mritiilvaparaenigaaaramktmgfsdlrivdsqahlepatrwvahgsgdiidnikvfptlaeslhdvdftvattarsrakyhyyatpvelvplleeksswmshaalvfgredsgltneelaladvltgvpmvadypslnlgqavmvycyqlatliqqpaksdatadqhqlqalreramtllttlavaddiklvdwlqqrlglleqrdtamlhrllhdieknitk Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=iaaA+AND+escherichia+coli Pubmed(iaaA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=iaaA Textpresso(iaaA)]


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Revision as of 23:50, 21 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

iaaA

Gene Synonym(s)

ECK0818, b0828, JW0812, spt, ybiK[1]

Product Desc.

IaaA[2][3];

Component of asparaginase III α-β complex[3]; asparaginase III[3]

isoAsp aminopeptidase, cleaves isoAsp-X dipeptides; Ntn hydrolase; glutathione utilization; weak L-asparaginase activity in vitro (EcAIII); precursor is cleaved into an alpha and beta subunit; heterotetrameric[4]

Product Synonyms(s)

L-asparaginase[1], B0828[2][1], Spt[2][1], YbiK[2][1]

Function from GO

Biological Process

Molecular Function

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): iaaA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(iaaA)    Textpresso(iaaA)

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

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IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. CysB regulon, sensitive to cysteine repression. Start of Salmonella iaaA is confirmed by N-terminal sequencing of IaaA precursor. Salmonella IaaA has been shown to have isoaspartyl-tripeptidase activity also; E. coli probably also has tripeptidase activity. iaaA is a non-essential gene.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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