degP:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''degP''  
''degP''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK0160, b0161, JW0157, htrA, ptd''<ref name='LIB:Riley_2006'/>
''ECK0160, b0161, JW0157, htrA, ptd''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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DegP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
DegP<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;  
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Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins<ref name='LIB:EcoGene'/>
Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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serine endoprotease (protease Do), membrane-associated<ref name='LIB:Riley_2006'/>, B0161<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ptd<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, protease Do<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
serine endoprotease (protease Do), membrane-associated<ref name='LIB:Riley_2006'/>, B0161<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Ptd<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, protease Do<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, HtrA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI,IDA])
* GO:0004252 serine-type endopeptidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA,IMP])
'''Biological Process'''
* GO:0006979 response to oxidative stress ([http://www.geneontology.org/GO.evidence.shtml IEP])
* GO:0006508 proteolysis ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0006515 misfolded or incompletely synthesized protein catabolic process ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0009266 response to temperature stimulus ([http://www.geneontology.org/GO.evidence.shtml IEP])
* GO:0006457 protein folding ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Cellular Component'''
* GO:0030288 outer membrane-bounded periplasmic space ([http://www.geneontology.org/GO.evidence.shtml IDA])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:degP|degP]]<ref name='LIB:EcoCyc10.6'/>, htrA  
transcription unit(s): [[:Category:Txn_unit:degP|degP]]<ref name='LIB:EcoCyc10.6'/>, htrA  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=degP&loc=MG1655:180884..182308,W3110:180884..182308,DH10B:154988..156412,REL606:183726..185150 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=183726&end=185150&gene=degP&aa=mkkttlalsalalslglalsplsataaetssattaqqmpslapmlekvmpsvvsinvegsttvntprmprnfqqffgddspfcqegspfqsspfcqggqggngggqqqkfmalgsgviidadkgyvvtnnhvvdnatvikvqlsdgrkfdakmvgkdprsdialiqiqnpknltaikmadsdalrvgdytvaignpfglgetvtsgivsalgrsglnaenyenfiqtdaainrgnsggalvnlngeligintailapdggnigigfaipsnmvknltsqmveygqvkrgelgimgtelnselakamkvdaqrgafvsqvlpnssaakagikagdvitslngkpissfaalraqvgtmpvgskltlgllrdgkqvnvnlelqqssqnqvdsssifngiegaemsnkgkdqgvvvnnvktgtpaaqiglkkgdviiganqqavkniaelrkvldskpsvlalniqrgdstiyllmq Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=degP+AND+escherichia+coli Pubmed(degP)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=degP Textpresso(degP)]


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Revision as of 00:04, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

degP

Gene Synonym(s)

ECK0160, b0161, JW0157, htrA, ptd[1]

Product Desc.

DegP[2][3];

Component of serine protease Do[3]

Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins[4]

Product Synonyms(s)

serine endoprotease (protease Do), membrane-associated[1], B0161[2][1], Ptd[2][1], protease Do[2][1], HtrA[2][1]

Function from GO

Molecular Function

Biological Process

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): degP[2], htrA

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(degP)    Textpresso(degP)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Autocleavage occurs after Cys95(Cys69 of mature form) or Gln108 (Gln82 of mature form). Autocleavage causes hexameric DegP(HtrA) to dissociate into proteolytically active monomers. Targeted to some proteins by CpxP. Sigma E promoter. Mutants have elevated OM vesiculation (McBroom, 2006). DegP(HtrA) has chaperone activity (Skorko-Glonek, 2007).[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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