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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''birA''  
''birA''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3965, b3973, JW3941, bioR, dhbB''<ref name='LIB:Riley_2006'/>
''ECK3965, b3973, JW3941, bioR, dhbB''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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Bifunctional biotin protein ligase, biotin operon repressor; biotin-[acetyl-CoA carboxylase] holoenzyme synthase; monomeric<ref name='LIB:EcoGene'/>
Bifunctional biotin protein ligase, biotin operon repressor; biotin-[acetyl-CoA carboxylase] holoenzyme synthase; monomeric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase and DNA-binding transcriptional repressor, bio-5'-AMP-binding<ref name='LIB:Riley_2006'/>, B3973<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BirA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BioR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DhbB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, biotin ligase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BirA transcriptional repressor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase and DNA-binding transcriptional repressor, bio-5'-AMP-binding<ref name='LIB:Riley_2006'/>, B3973<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BirA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BioR<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DhbB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, biotin ligase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, BirA transcriptional repressor<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0003677 DNA binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016564 transcription repressor activity ([http://www.geneontology.org/GO.evidence.shtml IEP])
* GO:0004077 biotin-(acetyl-CoA-carboxylase) ligase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0009102 biotin biosynthetic process ([http://www.geneontology.org/GO.evidence.shtml IMP])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IC])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:murB|murB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:murB|murB]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=birA&loc=MG1655:4171105..4172070,W3110:3463599..3462634,REL606:4152693..4153658,DH10B:4270802..4271767 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4270802&end=4271767&gene=birA&aa=mkdntvplkliallangefhsgeqlgetlgmsraainkhiqtlrdwgvdvftvpgkgyslpepiqllnakqilgqldggsvavlpvidstnqylldrigelksgdaciaeyqqagrgrrgrkwfspfganlylsmfwrleqgpaaaiglslvigivmaevlrklgadkvrvkwpndlylqdrklagilveltgktgdaaqivigaginmamrrveesvvnqgwitlqeaginldrntlaamlirelraalelfeqeglapylsrwekldnfinrpvkliigdkeifgisrgidkqgallleqdgiikpwmggeislrsaek Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=birA+AND+escherichia+coli Pubmed(birA)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=birA Textpresso(birA)]


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Revision as of 00:08, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

birA

Gene Synonym(s)

ECK3965, b3973, JW3941, bioR, dhbB[1]

Product Desc.

Bifunctional biotin protein ligase, biotin operon repressor; biotin-[acetyl-CoA carboxylase] holoenzyme synthase; monomeric[2]

Product Synonyms(s)

bifunctional biotin-[acetylCoA carboxylase] holoenzyme synthetase and DNA-binding transcriptional repressor, bio-5'-AMP-binding[1], B3973[3][1], BirA[3][1], BioR[3][1], DhbB[3][1], biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor[3][1], biotin ligase[3][1], BirA transcriptional repressor[3][1]

Function from GO

Molecular Function

Biological Process

Cellular Component

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): murB[3]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(birA)    Textpresso(birA)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Biotinyl-5'-AMP is the co-repressor and is also synthesized by BirA (Cronan, 1988). BirA biotinylates AccB on K122. The biotin operon is regulated by the rate of protein biotination (Cronan, 1989).[2]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
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