sdiA:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Standard Name
!align=left |Standard Name
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''sdiA''  
''sdiA''  
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!align=left {{table_heading_style}} |Gene Synonym(s)
!align=left |Gene Synonym(s)
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''ECK1915, b1916, JW1901, uvrX''<ref name='LIB:Riley_2006'/>
''ECK1915, b1916, JW1901, uvrX''<ref name='LIB:Riley_2006'/>
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!align=left {{table_heading_style}} |Product Desc.
!align=left |Product Desc.
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SdiA transcriptional activator<ref name='LIB:EcoCyc10.6'/>; SdiA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>
SdiA transcriptional activator<ref name='LIB:EcoCyc10.6'/>; SdiA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>
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Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones<ref name='LIB:EcoGene'/>
Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
!align=left |Product Synonyms(s)
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DNA-binding transcriptional activator<ref name='LIB:Riley_2006'/>, B1916<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SdiA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
DNA-binding transcriptional activator<ref name='LIB:Riley_2006'/>, B1916<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SdiA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:sdiA|sdiA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:sdiA|sdiA]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Regulation/Activity
!align=left |Regulation/Activity
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Revision as of 00:37, 10 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

sdiA

Gene Synonym(s)

ECK1915, b1916, JW1901, uvrX[1]

Product Desc.

SdiA transcriptional activator[2]; SdiA transcriptional dual regulator[3]

Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones[4]

Product Synonyms(s)

DNA-binding transcriptional activator[1], B1916[2][1], SdiA[2][1]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): sdiA[2]

Regulation/Activity


edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


Suppresses inhibitory effect of the MinC/MinD division inhibitor. N-acyl homoserine lactones act as folding switches for SdiA. LuxR family. SdiA has other global transcription targets such as uvrY, csrB, recN and nei. E. coli makes an unknown weak auto-inducer when grown in rich media. Most phenotypic effects require overproduction of SdiA. sdiA mutants are more sensitive to fluoroquinolones and have reduced AcrB protein, but are not defective in cell division. An sdiA ydiV double mutant has twofold reduced cAMP levels than inhibits quorum sensing system 2 (Zhou, 2008).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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