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The deoR gene is found immediately upstream of the operon. DeoR encodes a repressor protein that negatively regulates the expression of the operon at the level of transcription. A deoR-deficient mutant has a high level of deoxyriboaldolase and pyrimidine nucleoside phosphorylase.  <ref name='PMID:10074062'/>  In deoR mutations, the repressor is absent and the colonies of the mutants grow more rapidly (Munch-Peterson, et al, Eur. J. Biochem 27: 208-215 (1972)).
The ''deoR'' gene is found immediately upstream of the operon. ''DeoR'' encodes a repressor protein that negatively regulates the expression of the operon at the level of transcription. A ''deoR''-deficient mutant has a high level of ''deoxyriboaldolase'' and ''pyrimidine nucleoside phosphorylase''.  <ref name='PMID:10074062'/>  In ''deoR'' mutations, the repressor is absent and the colonies of the mutants grow more rapidly (Munch-Peterson, et al, Eur. J. Biochem 27: 208-215 (1972)).


==References==
==References==

Revision as of 07:59, 20 November 2007

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Gene Name

deoR (synonyms: ECK0830, b0840, JW0824, nucR)[1]

Product(s)

DeoR product[1]: DNA-binding transcriptional repressor product, B0840 product, NucR product, transcriptional repressor for deo operon, tsx, nupG product

Description

DeoR transcriptional repressor[2][3]

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): deoR[2]

Regulation/Activity
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The deoR gene is found immediately upstream of the operon. DeoR encodes a repressor protein that negatively regulates the expression of the operon at the level of transcription. A deoR-deficient mutant has a high level of deoxyriboaldolase and pyrimidine nucleoside phosphorylase. [4] In deoR mutations, the repressor is absent and the colonies of the mutants grow more rapidly (Munch-Peterson, et al, Eur. J. Biochem 27: 208-215 (1972)).

References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ Zeng, X & Saxild, HH (1999) Identification and characterization of a DeoR-specific operator sequence essential for induction of dra-nupC-pdp operon expression in Bacillus subtilis. J. Bacteriol. 181 1719-27 PubMed