Nonsense suppressor: Difference between revisions
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edited by JimHu via TableEdit |
edited by JimHu via TableEdit |
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[[serU]], [[serV]] | [[serU]], [[serV]] | ||
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Su-1, SuI, ftsM, su_1 | supD, supH, su1, Su-1, SuI, ftsM, su_1 | ||
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[[tRNA-Ser(CGA) (Serine tRNA2)| tRNA<sup>Ser</sup>(CGA) (Serine tRNA2)]] | [[tRNA-Ser(CGA) (Serine tRNA2)| tRNA<sup>Ser</sup>(CGA) (Serine tRNA2)]] | ||
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[[glnX]], [[glnV]] | [[glnX]], [[glnV]] | ||
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Su2, Su_II | supE, Su2, Su_II | ||
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[[tRNA-Gln(CUG) (Glutamine tRNA2)|tRNA<sup>Gln</sup>(CUG) (Glutamine tRNA2)]] | [[tRNA-Gln(CUG) (Glutamine tRNA2)|tRNA<sup>Gln</sup>(CUG) (Glutamine tRNA2)]] | ||
| | | | ||
Glutamine<ref name='PMID:4286570'/> | Glutamine<ref name='PMID:4286570'/> | ||
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Amber | |||
|- | |- | ||
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[[tyrT]] | [[tyrT]] | ||
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supF | |||
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[[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | [[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | ||
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Tyrosine<ref name='PMID:4286570'/> | Tyrosine<ref name='PMID:4286570'/> | ||
| | | | ||
Amber | |||
|- | |- | ||
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[[lysT]] | [[lysT]] | ||
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Su(beta), su-5, | supG, supK, supL, Su(beta), su-5, | ||
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[[tRNA-Lys(UUU) (Lysine tRNA)|tRNA<sup>Lys</sup>(UUU) (Lysine tRNA)]] | [[tRNA-Lys(UUU) (Lysine tRNA)|tRNA<sup>Lys</sup>(UUU) (Lysine tRNA)]] | ||
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[[leuX]] | [[leuX]] | ||
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Su-6 | supP, Su-6 | ||
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[[tRNA-Leu(CAA) (Leucine tRNA5)|tRNA<sup>Leu</sup>(CAA) (Leucine tRNA5)]] | [[tRNA-Leu(CAA) (Leucine tRNA5)|tRNA<sup>Leu</sup>(CAA) (Leucine tRNA5)]] | ||
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[[tyrT]] | [[tyrT]] | ||
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supC | |||
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[[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | [[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | ||
| | | | ||
Tyrosine<ref name='PMID:4286570'/> | Tyrosine<ref name='PMID:4286570'/> | ||
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Ochre | |||
|- | |||
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[[trpT]] | |||
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supU, supV, su9 | |||
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[[tRNA-Trp(CCA) (Tryptophan tRNA)|tRNA<sup>Trp</sup>(CCA) (Tryptophan tRNA)]] | |||
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Tryptophan | |||
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|- | |||
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[[tyrU]] | |||
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supZ | |||
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[[tRNA-Tyr(GUA) (Tyrosine tRNA2)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA2)]] | |||
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Tyrosine | |||
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Amber | |||
|- | |||
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[[glnU]] | |||
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supB | |||
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[[tRNA-Gln(UUG) (Glutamine tRNA1)|tRNA<sup>Gln</sup>(UUG) (Glutamine tRNA1)]] | |||
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Glutamine | |||
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Ochre | |||
|- | |||
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[[lysT]] | |||
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supL | |||
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[[tRNA-Lys(UUU) (Lysine tRNA)|tRNA<sup>Lys</sup>(UUU) (Lysine tRNA)]] | |||
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Lysine | |||
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Ochre | |||
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|[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.0.F46b4cf5d3f9bd&page=0&pagename={{FULLPAGENAMEE}} edit table] || || || || | |[{{SERVER}}/colipedia/index.php?title=Special:TableEdit&id=63ce1649aab8b3180235b0af7618f667.0.F46b4cf5d3f9bd&page=0&pagename={{FULLPAGENAMEE}} edit table] || || || || | ||
Revision as of 20:32, 4 August 2007
Nonsense suppressors change the effects of nonsense mutations by altering how stop codons are read. The largest class of nonsense suppressors are mutations in Category:tRNA genes that alter the codon-anticodon interaction to allow a stop codon to be read by that tRNA. This will only suppress the mutation if the amino acid inserted restores a functional protein product.
| gene | synonyms | tRNA affected | aa inserted | codons recognized |
|---|---|---|---|---|
|
supD, supH, su1, Su-1, SuI, ftsM, su_1 |
Serine [1] |
Amber | ||
|
supE, Su2, Su_II |
Glutamine[2] |
Amber | ||
|
supF |
Tyrosine[2] |
Amber | ||
supG, supK, supL, Su(beta), su-5, |
Ochre | |||
|
supP, Su-6 |
Amber | |||
|
supC |
Tyrosine[2] |
Ochre | ||
|
supU, supV, su9 |
Tryptophan |
|||
|
supZ |
Tyrosine |
Amber | ||
|
supB |
Glutamine |
Ochre | ||
|
supL |
Lysine |
Ochre | ||
| edit table |
See Also
- http://www.sci.sdsu.edu/~smaloy/MicrobialGenetics/topics/rev-sup/nonsense-suppressors.html Stan Maloy's page on nonsense suppressors
References
- ↑ WEIGERT, MG & GAREN, A (1965) AMINO ACID SUBSTITUTIONS RESULTING FROM SUPPRESSION OF NONSENSE MUTATIONS. I. SERINE INSERTION BY THE SU-1 SUPPRESSOR GENE. J. Mol. Biol. 12 448-55 PubMed
- ↑ 2.0 2.1 2.2 Weigert, MG et al. (1965) Amino acid substitutions resulting from suppression of nonsense mutations. II. Glutamine insertion by the Su-2 gene; tyrosine insertion by the Su-3 gene. J. Mol. Biol. 14 522-7 PubMed