Nonsense suppressor: Difference between revisions
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[[tRNA-Ser(CGA) (Serine tRNA2)| tRNA<sup>Ser</sup>(CGA) (Serine tRNA2)]] | [[tRNA-Ser(CGA) (Serine tRNA2)| tRNA<sup>Ser</sup>(CGA) (Serine tRNA2)]] | ||
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Serine <ref name='PMID:14337506'/> | Serine <ref name='PMID:14337506'/> | ||
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Amber | |||
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Su(beta), su-5, supG, supK, supL | Su(beta), su-5, supG, supK, supL | ||
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[[tRNA-Lys(UUU) (Lysine tRNA)|tRNA<sup>Lys</sup>(UUU) (Lysine tRNA)]] | |||
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Ochre | |||
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[[leuX]] | |||
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Su-6, supP | |||
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[[tRNA-Leu(CAA) (Leucine tRNA5)|tRNA<sup>Leu</sup>(CAA) (Leucine tRNA5)]] | |||
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Amber | |||
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[[tyrT]] | |||
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Su-3, Su-4, suI_III, su_III, supC, supF, supO | |||
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[[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | |||
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Tyrosine<ref name='PMID:4286570'/> | |||
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Revision as of 20:10, 4 August 2007
Nonsense suppressors change the effects of nonsense mutations by altering how stop codons are read. The largest class of nonsense suppressors are mutations in Category:tRNA genes that alter the codon-anticodon interaction to allow a stop codon to be read by that tRNA. This will only suppress the mutation if the amino acid inserted restores a functional protein product.
| gene | synonyms | tRNA affected | aa inserted | codons recognized |
|---|---|---|---|---|
|
Su-1, SuI, ftsM, su_1, supD, supH, su1 |
Serine [1] |
Amber | ||
|
Su2, Su_II, supE |
Glutamine[2] |
|||
|
Su-3, Su-4, suI_III, su_III, supC, supF, supO |
Tyrosine[2] |
|||
|
Su(beta), su-5, supG, supK, supL |
Ochre | |||
|
Su-6, supP |
Amber | |||
|
Su-3, Su-4, suI_III, su_III, supC, supF, supO |
Tyrosine[2] |
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| edit table |
See Also
- http://www.sci.sdsu.edu/~smaloy/MicrobialGenetics/topics/rev-sup/nonsense-suppressors.html Stan Maloy's page on nonsense suppressors
References
- ↑ WEIGERT, MG & GAREN, A (1965) AMINO ACID SUBSTITUTIONS RESULTING FROM SUPPRESSION OF NONSENSE MUTATIONS. I. SERINE INSERTION BY THE SU-1 SUPPRESSOR GENE. J. Mol. Biol. 12 448-55 PubMed
- ↑ 2.0 2.1 2.2 Weigert, MG et al. (1965) Amino acid substitutions resulting from suppression of nonsense mutations. II. Glutamine insertion by the Su-2 gene; tyrosine insertion by the Su-3 gene. J. Mol. Biol. 14 522-7 PubMed