Nonsense suppressor: Difference between revisions
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serU, serV | [[serU]], [[serV]] | ||
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Su-1, SuI, ftsM, su_1, supD, supH, su1 | Su-1, SuI, ftsM, su_1, supD, supH, su1 | ||
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Glutamine<ref name='PMID:4286570'/> | Glutamine<ref name='PMID:4286570'/> | ||
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[[tyrT]] | |||
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Su-3, Su-4, suI_III, su_III, supC, supF, supO | |||
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[[tRNA-Tyr(GUA) (Tyrosine tRNA1)|tRNA<sup>Tyr</sup>(GUA) (Tyrosine tRNA1)]] | |||
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Tyrosine<ref name='PMID:4286570'/> | |||
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Revision as of 19:36, 4 August 2007
Nonsense suppressors change the effects of nonsense mutations by altering how stop codons are read. The largest class of nonsense suppressors are mutations in Category:tRNA genes that alter the codon-anticodon interaction to allow a stop codon to be read by that tRNA. This will only suppress the mutation if the amino acid inserted restores a functional protein product.
| gene | synonyms | tRNA affected | aa inserted |
|---|---|---|---|
|
Su-1, SuI, ftsM, su_1, supD, supH, su1 |
Serine [1] | ||
|
Su2, Su_II, supE |
Glutamine[2] | ||
|
Su-3, Su-4, suI_III, su_III, supC, supF, supO |
Tyrosine[2] | ||
| edit table |
- ↑ WEIGERT, MG & GAREN, A (1965) AMINO ACID SUBSTITUTIONS RESULTING FROM SUPPRESSION OF NONSENSE MUTATIONS. I. SERINE INSERTION BY THE SU-1 SUPPRESSOR GENE. J. Mol. Biol. 12 448-55 PubMed
- ↑ 2.0 2.1 Weigert, MG et al. (1965) Amino acid substitutions resulting from suppression of nonsense mutations. II. Glutamine insertion by the Su-2 gene; tyrosine insertion by the Su-3 gene. J. Mol. Biol. 14 522-7 PubMed