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!align=left |Citation | |||
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'''No author listed''' (1979) Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli. ''J. Bacteriol.'' '''139''':701-4 | |||
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!align=left |Abstract | |||
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A new Escherichia coli deoxyribonucleic acid (DNA) ligase mutant has been identified among a collection of temperature-sensitive DNA replication mutants isolated recently (Sevastopoulos, Wehr, and Glaser, Proc. Natl. Acad. Sci. U.S.A. 74:3485-3489, 1977). At the nonpermissive temperature DNA synthesis in the mutant stops rapidly, the DNA is degraded to acid-soluble material, and cell death ensures. This suggests that the mutant may be among the most ligase-deficient strains yet characterized. | |||
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!align=left |Links | |||
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=378985 PubMed] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC216928 PMC216928] | |||
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| | !align=left |Keywords | ||
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|{{ | Chromosome Mapping; Chromosomes, Bacterial; DNA Ligases/genetics; DNA Ligases/metabolism; DNA Replication; DNA, Bacterial/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Genes; Mutation; Polynucleotide Ligases/genetics | ||
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==Significance {{HelpIcon|Help:Literature}} == | ==Significance {{HelpIcon|Help:Literature}} == | ||
{{LitSignificance}} | {{LitSignificance}} | ||
Revision as of 19:26, 1 September 2013
| Citation |
No author listed (1979) Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli. J. Bacteriol. 139:701-4 |
|---|---|
| Abstract |
A new Escherichia coli deoxyribonucleic acid (DNA) ligase mutant has been identified among a collection of temperature-sensitive DNA replication mutants isolated recently (Sevastopoulos, Wehr, and Glaser, Proc. Natl. Acad. Sci. U.S.A. 74:3485-3489, 1977). At the nonpermissive temperature DNA synthesis in the mutant stops rapidly, the DNA is degraded to acid-soluble material, and cell death ensures. This suggests that the mutant may be among the most ligase-deficient strains yet characterized. |
| Links | |
| Keywords |
Chromosome Mapping; Chromosomes, Bacterial; DNA Ligases/genetics; DNA Ligases/metabolism; DNA Replication; DNA, Bacterial/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Genes; Mutation; Polynucleotide Ligases/genetics |
| edit table |
Significance
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Useful Materials and Methods
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Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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