PMID:378985
| Citation |
Dermody, JJ, Robinson, GT and Sternglanz, R (1979) Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli. J. Bacteriol. 139:701-4 |
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| Abstract |
A new Escherichia coli deoxyribonucleic acid (DNA) ligase mutant has been identified among a collection of temperature-sensitive DNA replication mutants isolated recently (Sevastopoulos, Wehr, and Glaser, Proc. Natl. Acad. Sci. U.S.A. 74:3485-3489, 1977). At the nonpermissive temperature DNA synthesis in the mutant stops rapidly, the DNA is degraded to acid-soluble material, and cell death ensures. This suggests that the mutant may be among the most ligase-deficient strains yet characterized. |
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| Keywords |
Chromosome Mapping; Chromosomes, Bacterial; DNA Ligases/genetics; DNA Ligases/metabolism; DNA Replication; DNA, Bacterial/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Genes; Mutation; Polynucleotide Ligases/genetics |
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