Septation: Difference between revisions
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==Regulation {{HelpIcon|Help:Processes}}== | ==Regulation {{HelpIcon|Help:Processes}}== | ||
Z ring formation can be inhibited by sulA (recA- dependent SOS response) | Z ring formation can be inhibited by sulA (recA- dependent SOS response) or by the action of the Min system<ref name='PMID:17085577'/>. | ||
SOS gets triggered in response to DNA damage. ''sulA'' is one of many genes whose expression gets upregulates upon LexA repressor cleavage<ref name='PMID:9068638'/>. The SulA protein directly binds to monomeric FtsZ and inhibits its polymerization<ref name='PMID:12808143'/>. | |||
==Cell Biology {{HelpIcon|Help:Processes}}== | ==Cell Biology {{HelpIcon|Help:Processes}}== | ||
Revision as of 16:51, 4 June 2010
General Description
Invagination of the membrane that occurs after replication to separate daughter cells.
Components
FtsZ(Z ring), FtsA, FtsK, FtsN, FtsI, FtsE, FtsX, etc.
In order to ensure the chromosome doesn't get guillotined, TopoIV and the XerCD recombinase are also localized to the septa, via FtsK, but they are not involved directly in the membrane closure.
Function
Regulation
Z ring formation can be inhibited by sulA (recA- dependent SOS response) or by the action of the Min system[2]. SOS gets triggered in response to DNA damage. sulA is one of many genes whose expression gets upregulates upon LexA repressor cleavage[3]. The SulA protein directly binds to monomeric FtsZ and inhibits its polymerization[4].
Cell Biology
Experimental Resources
Comparison with other organisms
Notes
Some of the experiments that helped to order the components of this recruitment pathway can be found in Chen et al. (1999)[5], Weiss et al. (1999)[6], Ghigo et al. (1999)[7], and Mercer and Weiss (2002)[8].
References
See Help:References for how to manage references in EcoliWiki.
- ↑ Geissler, B & Margolin, W (2005) Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol. Microbiol. 58 596-612 PubMed
- ↑ Shiomi, D & Margolin, W (2007) The C-terminal domain of MinC inhibits assembly of the Z ring in Escherichia coli. J. Bacteriol. 189 236-43 PubMed
- ↑ Hill, TM et al. (1997) sfi-independent filamentation in Escherichia coli Is lexA dependent and requires DNA damage for induction. J. Bacteriol. 179 1931-9 PubMed
- ↑ Cordell, SC et al. (2003) Crystal structure of the SOS cell division inhibitor SulA and in complex with FtsZ. Proc. Natl. Acad. Sci. U.S.A. 100 7889-94 PubMed
- ↑ Chen, JC & Beckwith, J (2001) FtsQ, FtsL and FtsI require FtsK, but not FtsN, for co-localization with FtsZ during Escherichia coli cell division. Mol. Microbiol. 42 395-413 PubMed
- ↑ Weiss, DS et al. (1999) Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J. Bacteriol. 181 508-20 PubMed
- ↑ Ghigo, JM et al. (1999) Localization of FtsL to the Escherichia coli septal ring. Mol. Microbiol. 31 725-37 PubMed
- ↑ Mercer, KL & Weiss, DS (2002) The Escherichia coli cell division protein FtsW is required to recruit its cognate transpeptidase, FtsI (PBP3), to the division site. J. Bacteriol. 184 904-12 PubMed