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!align=left {{table_heading_style}} |Function from GO
!align=left {{table_heading_style}} |Function from GO
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'''Biological Process'''
<GO_nr />
* GO:0009063 amino acid catabolic process ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0006530 asparagine catabolic process ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Molecular Function'''
* GO:0016787 hydrolase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0004067 asparaginase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0004177 aminopeptidase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IC])
 
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype

Revision as of 19:38, 2 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

iaaA

Gene Synonym(s)

ECK0818, b0828, JW0812, spt, ybiK[1]

Product Desc.

IaaA[2][3];

Component of asparaginase III α-β complex[3]; asparaginase III[3]

isoAsp aminopeptidase, cleaves isoAsp-X dipeptides; Ntn hydrolase; glutathione utilization; weak L-asparaginase activity in vitro (EcAIII); precursor is cleaved into an alpha and beta subunit; heterotetrameric[4]

Product Synonyms(s)

L-asparaginase[1], B0828[2][1], Spt[2][1], YbiK[2][1]

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): iaaA[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(iaaA)    Textpresso(iaaA)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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IaaA is cleaved before Thr179 to expose N-terminal nucleophile and to produce two subunits. CysB regulon, sensitive to cysteine repression. Start of Salmonella iaaA is confirmed by N-terminal sequencing of IaaA precursor. Salmonella IaaA has been shown to have isoaspartyl-tripeptidase activity also; E. coli probably also has tripeptidase activity. iaaA is a non-essential gene.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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