recQ:Quickview: Difference between revisions

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!align=left |Standard Name
!align=left {{table_heading_style}} |Standard Name
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''recQ''  
''recQ''  
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!align=left |Gene Synonym(s)
!align=left {{table_heading_style}} |Gene Synonym(s)
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''ECK3816, b3822, JW5855''<ref name='LIB:Riley_2006'/>
''ECK3816, b3822, JW5855''<ref name='LIB:Riley_2006'/>
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!align=left |Product Desc.
!align=left {{table_heading_style}} |Product Desc.
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ATP-dependent DNA helicase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
ATP-dependent DNA helicase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
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DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric<ref name='LIB:EcoGene'/>
DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric<ref name='LIB:EcoGene'/>
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!align=left |Product Synonyms(s)
!align=left {{table_heading_style}} |Product Synonyms(s)
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ATP-dependent DNA helicase<ref name='LIB:Riley_2006'/>, B3822<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
ATP-dependent DNA helicase<ref name='LIB:Riley_2006'/>, B3822<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
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!align=left |Knock-Out Phenotype
!align=left {{table_heading_style}} |Function from GO
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'''Molecular Function'''
* GO:0046914 transition metal ion binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0016887 ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0008094 DNA-dependent ATPase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0004003 ATP-dependent DNA helicase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0003677 DNA binding ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0008270 zinc ion binding ([http://www.geneontology.org/GO.evidence.shtml IMP])
* GO:0005524 ATP binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
* GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0005515 protein binding ([http://www.geneontology.org/GO.evidence.shtml IPI])
'''Cellular Component'''
* GO:0005737 cytoplasm ([http://www.geneontology.org/GO.evidence.shtml IDA])
* GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex ([http://www.geneontology.org/GO.evidence.shtml IDA])
'''Biological Process'''
* GO:0006310 DNA recombination ([http://www.geneontology.org/GO.evidence.shtml IMP,IDA])
* GO:0006281 DNA repair ([http://www.geneontology.org/GO.evidence.shtml IGI])
* GO:0006974 response to DNA damage stimulus ([http://www.geneontology.org/GO.evidence.shtml IGI])


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!align=left |Regulation/Expression
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:recQ|recQ]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:recQ|recQ]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[http://ecoliwiki.net/tools/display_dna.php?gene=recQ&loc=MG1655:4003887..4005716,W3110:3630817..3628988,REL606:3970285..3972120,DH10B:4102807..4104636 DNA display]&nbsp;&nbsp;&nbsp; [http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4102807&end=4104636&gene=recQ&aa=maqaevlnlesgakqvlqetfgyqqfrpgqeeiidtvlsgrdclvvmptgggkslcyqipalllngltvvvsplislmkdqvdqlqangvaaaclnstqtreqqlevmtgcrtgqirllyiaperlmldnflehlahwnpvllavdeahcisqwghdfrpeyaalgqlrqrfptlpfmaltataddttrqdivrllglndpliqissfdrpnirymlmekfkpldqlmryvqeqrgksgiiycnsrakvedtaarlqskgisaaayhaglennvradvqekfqrddlqivvatvafgmginkpnvrfvvhfdiprniesyyqetgragrdglpaeamlfydpadmawlrrcleekpqgqlqdierhklnamgafaeaqtcrrlvllnyfgegrqepcgncdicldppkqydgstdaqialstigrvnqrfgmgyvvevirgannqrirdyghdklkvygmgrdkshehwvsvirqlihlglvtqniaqhsalqlteaarpvlrgesslqlavprivalkpkamqksfggnydrklfaklrklrksiadesnvppyvvfndatliemaeqmpitasemlsvngvgmrklerfgkpfmalirahvdgddee Protein display]&nbsp;&nbsp;&nbsp; [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=recQ+AND+escherichia+coli Pubmed(recQ)]&nbsp;&nbsp;&nbsp; [http://trimer.tamu.edu/cgi-bin/textpresso/2.1/ecoli/search?searchstring=recQ Textpresso(recQ)]


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Revision as of 00:30, 22 January 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

See Help:Quickview for help with entering information in the Quickview table.

Standard Name

recQ

Gene Synonym(s)

ECK3816, b3822, JW5855[1]

Product Desc.

ATP-dependent DNA helicase[2][3]

DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4]

Product Synonyms(s)

ATP-dependent DNA helicase[1], B3822[2][1], RecQ[2][1]

Function from GO

Molecular Function

Cellular Component

Biological Process

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): recQ[2]

Regulation/Activity
Quick Links

DNA display    Protein display    Pubmed(recQ)    Textpresso(recQ)

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See Help:Quickview for help with entering information in the Quickview table.

Notes

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Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. RecQ is involved with recombinational repair within the RecF pathway. Specifically, recQ is used for double stranded DNA break (DSB) repair by generating the single stranded DNA. This ssDNA is then processed by other enzymes in the RecF pathway, which manipulate the ssDNA so it will be competent for recombination. [5]

Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. [6]

SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). LexA regulon.[4]



References

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  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Killoran, MP & Keck, JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34 4098-105 PubMed
  6. ↑ Mohaghegh, P & Hickson, ID (2001) DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum. Mol. Genet. 10 741-6 PubMed
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