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{{Tab On|Quickview|recQ}}{{Tab|Gene|recQ}}{{Tab|Gene Product(s)|recQ}}{{Tab|Expression|recQ}}{{Tab|Evolution|recQ}}{{Tab|On One Page|recQ}}{{TabsBottom}}
{{Tab On|Quickview|recQ}}{{Tab|Gene|recQ}}{{Tab|Gene Product(s)|recQ}}{{Tab|Expression|recQ}}{{Tab|Evolution|recQ}}{{Tab|On One Page|recQ}}{{TabsBottom}}
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{|   id="E49b0220985cb6"  class=" tableEdit New_Quickview_Table" 
 
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[recQ:Gene|''recQ]]'' (synonyms: ''ECK3816, b3822, JW5855'')<ref name='LIB:Riley_2006'/>
''recQ''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[recQ:Gene_Product(s)|RecQ product]]<ref name='LIB:Riley_2006'/>: ATP-dependent DNA helicase product, B3822 product
''ECK3816, b3822, JW5855''<ref name='LIB:Riley_2006'/>, JW5855''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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ATP-dependent DNA helicase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
ATP-dependent DNA helicase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric<ref name='LIB:EcoGene'/>
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''ATP-dependent DNA helicase<ref name='LIB:Riley_2006'/>, B3822<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RecQ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3816, JW5855, b3822''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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|-
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:recQ|recQ]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:recQ|recQ]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=recQ&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10833]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000824&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=recQ&loc=MG1655%3A4003887..4005716,W3110%3A3630817..3628988,REL606%3A3970285..3972120,DH10B%3A4102807..4104636,BW2952%3A3893556..3895385]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3893556&end=3895385&gene=recQ&aa=maqaevlnlesgakqvlqetfgyqqfrpgqeeiidtvlsgrdclvvmptgggkslcyqipalllngltvvvsplislmkdqvdqlqangvaaaclnstqtreqqlevmtgcrtgqirllyiaperlmldnflehlahwnpvllavdeahcisqwghdfrpeyaalgqlrqrfptlpfmaltataddttrqdivrllglndpliqissfdrpnirymlmekfkpldqlmryvqeqrgksgiiycnsrakvedtaarlqskgisaaayhaglennvradvqekfqrddlqivvatvafgmginkpnvrfvvhfdiprniesyyqetgragrdglpaeamlfydpadmawlrrcleekpqgqlqdierhklnamgafaeaqtcrrlvllnyfgegrqepcgncdicldppkqydgstdaqialstigrvnqrfgmgyvvevirgannqrirdyghdklkvygmgrdkshehwvsvirqlihlglvtqniaqhsalqlteaarpvlrgesslqlavprivalkpkamqksfggnydrklfaklrklrksiadesnvppyvvfndatliemaeqmpitasemlsvngvgmrklerfgkpfmalirahvdgddee]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=recQ+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=recQ]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. RecQ is involved with recombinational repair within the RecF pathway. Specifically, recQ is used for double stranded DNA break (DSB) repair by generating the single stranded DNA. This ssDNA is then processed by other enzymes in the RecF pathway, which manipulate the ssDNA so it will be competent for recombination. <ref name= 'PMID: 16935877'/>
 
Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. <ref name= 'PMID: 11257107'/>
 
SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). LexA regulon.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:56, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

recQ

Gene Synonym(s)

ECK3816, b3822, JW5855[1], JW5855

Product Desc.

ATP-dependent DNA helicase[2][3]

DNA helicase involved in recombination, replication, repair; ATP-dependent; monomeric[4]

Product Synonyms(s)

ATP-dependent DNA helicase[1], B3822[2][1], RecQ[2][1] , ECK3816, JW5855, b3822

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): recQ[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Helicases generally separate duplex nucleic acids into separate strands. RecQ helicase couples the energy of ATP hydrolysis in order to unwind double-stranded DNA and RNA molecules. RecQ is involved with recombinational repair within the RecF pathway. Specifically, recQ is used for double stranded DNA break (DSB) repair by generating the single stranded DNA. This ssDNA is then processed by other enzymes in the RecF pathway, which manipulate the ssDNA so it will be competent for recombination. [5]

Associated syndromes with mutations on the recQ gene include Werner's, Bloom's, and Rothmund-Thomson Syndrome, which are all autosomal recessive disorders. Werner's Syndrome occurs due to a mutation on the WRN gene and causes loss of skin elasticity, osteoporosis, and atherosclerosis in humans. Bloom's occurs on the BLM gene and is associated with immuno-deficiency, male infertility, and predisposition to all types of cancer. Rothmund-Thomson syndrome is due to a mutation on the RECQ4 gene and causes growth deficiency, early graying and hair loss, and increased cancer incidence in humans. [6]

SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). LexA regulon.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Killoran, MP & Keck, JL (2006) Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res. 34 4098-105 PubMed
  6. ↑ Mohaghegh, P & Hickson, ID (2001) DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum. Mol. Genet. 10 741-6 PubMed
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