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{{Tab On|Quickview|sdiA}}{{Tab|Gene|sdiA}}{{Tab|Gene Product(s)|sdiA}}{{Tab|Expression|sdiA}}{{Tab|Evolution|sdiA}}{{Tab|On One Page|sdiA}}{{TabsBottom}}
{{Tab On|Quickview|sdiA}}{{Tab|Gene|sdiA}}{{Tab|Gene Product(s)|sdiA}}{{Tab|Expression|sdiA}}{{Tab|Evolution|sdiA}}{{Tab|On One Page|sdiA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[sdiA:Gene|''sdiA]]'' (synonyms: ''ECK1915, b1916, JW1901, uvrX'')<ref name='LIB:Riley_2006'/>
''sdiA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[sdiA:Gene_Product(s)|SdiA product]]<ref name='LIB:Riley_2006'/>: DNA-binding transcriptional activator product, B1916 product
''ECK1915, b1916, JW1901, uvrX''<ref name='LIB:Riley_2006'/>, uvrX''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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SdiA transcriptional activator<ref name='LIB:EcoCyc10.6'/> SdiA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>  
SdiA transcriptional activator<ref name='LIB:EcoCyc10.6'/>; SdiA transcriptional dual regulator<ref name='LIB:EcoCyc11.1'/>


Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''DNA-binding transcriptional activator<ref name='LIB:Riley_2006'/>, B1916<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SdiA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK1915, JW1901, uvrX, b1916''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:sdiA|sdiA]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:sdiA|sdiA]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=sdiA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10935]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000924&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=sdiA&loc=MG1655%3A1994856..1994134,W3110%3A1998969..1998247,DH10B%3A2085864..2085142,BW2952%3A1886617..1887339]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=1886617&end=1887339&gene=sdiA&aa=mqdkdffswrrtmllrfqrmetaeevyheielqaqqleydyyslcvrhpvpftrpkvafytnypeawvsyyqaknflaidpvlnpenfsqghlmwnddlfseaqplweaarahglrrgvtqylmlpnralgflsfsrcsareipilsdelqlkmqllvreslmalmrlndeivmtpemnfskrekeilrwtaegktsaeiamilsisentvnfhqknmqkkinapnktqvacyaaatgli]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=sdiA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=sdiA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Suppresses inhibitory effect of the MinC/MinD division inhibitor. N-acyl homoserine lactones act as folding switches for SdiA. LuxR family. SdiA has other global transcription targets such as uvrY, csrB, recN and nei. E. coli makes an unknown weak auto-inducer when grown in rich media. Most phenotypic effects require overproduction of SdiA. sdiA mutants are more sensitive to fluoroquinolones and have reduced AcrB protein, but are not defective in cell division. An sdiA ydiV double mutant has twofold reduced cAMP levels than inhibits quorum sensing system 2 (Zhou, 2008).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:46, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

sdiA

Gene Synonym(s)

ECK1915, b1916, JW1901, uvrX[1], uvrX

Product Desc.

SdiA transcriptional activator[2]; SdiA transcriptional dual regulator[3]

Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones[4]

Product Synonyms(s)

DNA-binding transcriptional activator[1], B1916[2][1], SdiA[2][1] , ECK1915, JW1901, uvrX, b1916

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): sdiA[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Suppresses inhibitory effect of the MinC/MinD division inhibitor. N-acyl homoserine lactones act as folding switches for SdiA. LuxR family. SdiA has other global transcription targets such as uvrY, csrB, recN and nei. E. coli makes an unknown weak auto-inducer when grown in rich media. Most phenotypic effects require overproduction of SdiA. sdiA mutants are more sensitive to fluoroquinolones and have reduced AcrB protein, but are not defective in cell division. An sdiA ydiV double mutant has twofold reduced cAMP levels than inhibits quorum sensing system 2 (Zhou, 2008).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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