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{{Tab On|Quickview|msbA}}{{Tab|Gene|msbA}}{{Tab|Gene Product(s)|msbA}}{{Tab|Expression|msbA}}{{Tab|Evolution|msbA}}{{Tab|On One Page|msbA}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[msbA:Gene|''msbA]]'' (synonyms: ''ECK0905, b0914, JW0897'')<ref name='LIB:Riley_2006'/>
''msbA''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[msbA:Gene_Product(s)|MsbA product]]<ref name='LIB:Riley_2006'/>: fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/>, MsbA<ref name='LIB:EcoCyc10.6'/>
''ECK0905, b0914, JW0897''<ref name='LIB:Riley_2006'/>, JW0897''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
ATP-binding transport protein<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''fused lipid transporter subunits of ABC superfamily: membrane component<ref name='LIB:Riley_2006'/>, ATP-binding component<ref name='LIB:Riley_2006'/>, B0914<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MsbA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ECK0905, JW0897, b0914''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:ycaI|ycaI]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ycaI|ycaI]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=msbA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10613]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000606&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=msbA&loc=MG1655%3A965844..967592,W3110%3A967043..968791,DH10B%3A1019772..1021520,REL606%3A983713..985461,BW2952%3A868812..870560]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=868812&end=870560&gene=msbA&aa=mhndkdlstwqtfrrlwptiapfkaglivagvalilnaasdtfmlsllkpllddgfgktdrsvlvwmplvviglmilrgitsyvssyciswvsgkvvmtmrrrlfghmmgmpvsffdkqstgtllsritydseqvassssgalitvvregasiiglfimmfyyswqlsiilivlapivsiairvvskrfrnisknmqntmgqvttsaeqmlkghkevlifggqevetkrfdkvsnrmrlqgmkmvsassisdpiiqliaslalafvlyaasfpsvmdsltagtitvvfssmialmrplksltnvnaqfqrgmaacqtlftildseqekdegkrvieratgdvefrnvtftypgrdvpalrninlkipagktvalvgrsgsgkstiaslitrfydidegeilmdghdlreytlaslrnqvalvsqnvhlfndtvanniayarteqysreqieeaarmayamdfinkmdngldtvigengvllsggqrqriaiarallrdspilildeatsaldteseraiqaaldelqknrtslviahrlstiekadeivvvedgvivergthndllehrgvyaqlhkmqfgq]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=msbA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=msbA]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
MsbA PDB structures 1JSQ, 1PF4 and 1Z2R, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006). A yhjD point mutation (R134C) allows the deletion of the otherwise essential msbA gene (Mamat, 2007). MsbA point mutations confering S18P or S50P suppress the lethal phenotype of a KDO null gutQ kdsD double mutant (Mamat, 2007).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:47, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

msbA

Gene Synonym(s)

ECK0905, b0914, JW0897[1], JW0897

Product Desc.

ATP-binding transport protein[2][3]

Lipid exporter to the outer membrane; exports LPS, phospholipids, and lipid A; drug export and resistance; ABC transporter flippase; biogenesis of outer membrane; lipid-activated ATPase[4]

Product Synonyms(s)

fused lipid transporter subunits of ABC superfamily: membrane component[1], ATP-binding component[1], B0914[2][1], MsbA[2][1], ECK0905, JW0897, b0914

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ycaI[2]

Regulation/Activity
Quick Links



        

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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


MsbA PDB structures 1JSQ, 1PF4 and 1Z2R, and any conclusions derived from these structures, have been retracted due to a software data inversion error (Chang, 2006). A yhjD point mutation (R134C) allows the deletion of the otherwise essential msbA gene (Mamat, 2007). MsbA point mutations confering S18P or S50P suppress the lethal phenotype of a KDO null gutQ kdsD double mutant (Mamat, 2007).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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