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{{Tab On|Quickview|ampG}}{{Tab|Gene|ampG}}{{Tab|Gene Product(s)|ampG}}{{Tab|Expression|ampG}}{{Tab|Evolution|ampG}}{{Tab|On One Page|ampG}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[ampG:Gene|''ampG]]'' (synonyms: ''ECK0427, b0433, JW0423'')<ref name='LIB:Riley_2006'/>
''ampG''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[ampG:Gene_Product(s)|AmpG product]]<ref name='LIB:Riley_2006'/>: muropeptide transporter<ref name='LIB:Riley_2006'/>, B0433<ref name='LIB:EcoCyc10.6'/>, AmpG<ref name='LIB:EcoCyc10.6'/>
''ECK0427, b0433, JW0423''<ref name='LIB:Riley_2006'/>, JW0423''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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AmpG muropeptide MFS transporter<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
AmpG muropeptide MFS transporter<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Muropeptide permease, imports GlcNAc-anhMurNAc-peptides; required for cloned Citrobacter freundii AmpR-regulated beta-lactamase induction and murein recycling<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''muropeptide transporter<ref name='LIB:Riley_2006'/>, B0433<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, AmpG<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0427, JW0423, b0433''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:ampG|ampG]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:ampG|ampG]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=ampG&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG12183]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120002076&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=ampG&loc=MG1655%3A452769..451294,W3110%3A452769..451294,DH10B%3A392100..390625,REL606%3A424250..422775,BW2952%3A354053..355528]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=354053&end=355528&gene=ampG&aa=mssqylrifqqprsaillilgfasglplaltsgtlqawmtvenidlktigffslvgqayvfkflwsplmdrytppffgrrrgwllatqilllvaiaamgflepgtqlrwmaalavviafcsasqdivfdawktdvlpaeergagaaisvlgyrlgmlvsgglalwladkwlgwqgmywlmaallipciiatllapeptdtipvpktleqavvaplrdffgrnnawlilllivlyklgdafamsltttflirgvgfdagevgvvnktlgllativgalyggilmqrlslfrallifgilqgasnagywllsitdkhlysmgaavffenlcggmgtsafvallmtlcnksfsatqfallsalsavgrvyvgpvagwfveahgwstfylfsvaaavpglilllvcrqtleytrvndnfisrtaypagyafamwtlaagvsllavwlllltmdaldlthfsflpallevgvlvalsgvvlgglldylalrkthlt]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=ampG+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=ampG]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. Mutants accumulate GlcNAc-anhMurNAc-tripeptide. Transport inhibited by CCCP. 14 TM helices are [predicted, but fusion studies indicate that predicted hydrophobic helices 5, 6, 11, and 12 are in cytoplasmic loops; AmpG probably has 10 TM helices with N-in, C-in topology. AmpG has been studied using cloned Citrobacter freundii ampR and ampC genes, which are normally on the chromosome of C. freundii. This C. freundii ampC is not the same as the E. coli weak constitutive chromosomal ampC beta-lactamase; E. coli has no ampR gene. Major Facilitator Superfamily (MFS).<ref name='LIB:EcoGene'/>
 




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==References==
==References==
{{BacktoTop}}
<references/>
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Latest revision as of 21:53, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

ampG

Gene Synonym(s)

ECK0427, b0433, JW0423[1], JW0423

Product Desc.

AmpG muropeptide MFS transporter[2][3]

Muropeptide permease, imports GlcNAc-anhMurNAc-peptides; required for cloned Citrobacter freundii AmpR-regulated beta-lactamase induction and murein recycling[4]

Product Synonyms(s)

muropeptide transporter[1], B0433[2][1], AmpG[2][1] , ECK0427, JW0423, b0433

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): ampG[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


Imported muropeptides must contain the disaccharide GlcNAc-anhMurNAc, which is also efficiently transported without attached peptides. Mutants accumulate GlcNAc-anhMurNAc-tripeptide. Transport inhibited by CCCP. 14 TM helices are [predicted, but fusion studies indicate that predicted hydrophobic helices 5, 6, 11, and 12 are in cytoplasmic loops; AmpG probably has 10 TM helices with N-in, C-in topology. AmpG has been studied using cloned Citrobacter freundii ampR and ampC genes, which are normally on the chromosome of C. freundii. This C. freundii ampC is not the same as the E. coli weak constitutive chromosomal ampC beta-lactamase; E. coli has no ampR gene. Major Facilitator Superfamily (MFS).[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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