mcrB:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[mcrB:Gene|''mcrB]]'' (synonyms: ''ECK4336, b4346, JW5871, rglB'')<ref name='LIB:Riley_2006'/>
''mcrB''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[mcrB:Gene_Product(s)|McrB product]]<ref name='LIB:Riley_2006'/>: 5-methylcytosine-specific restriction enzyme McrBC, subunit McrB product, B4346 product, RglB product
''ECK4336, b4346, JW5871, rglB''<ref name='LIB:Riley_2006'/>, rglB''
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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MrcB subunit of 5-methylcytosine restriction system<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
McrB subunit of 5-methylcytosine restriction system<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:McrBC restriction endonuclease|McrBC restriction endonuclease]]<ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:McrBC restriction endonuclease|McrBC restriction endonuclease]]<ref name='LIB:EcoCyc11.1'/>


McrBC restriction endonuclease, catalytic subunit; 5-methylcytosine-specific; requires GTP, inhibited by ATP<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''5-methylcytosine-specific restriction enzyme McrBC, subunit McrB<ref name='LIB:Riley_2006'/>, B4346<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, RglB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, McrB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4336, JW5871, rglB, b4346''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:mcrBC|mcrBC]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mcrBC|mcrBC]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=mcrB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10574]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000567&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=mcrB&loc=MG1655%3A4577360..4575981,W3110%3A4584017..4582638,REL606%3A4557282..4555903,BW2952%3A4514465..4515844]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=4514465&end=4515844&gene=mcrB&aa=mrkaylmesiqpwiekfikqaqqqrsqstkdyptsyrnlrvklsfgygnftsipwfaflgegqeasngiypvilyykdfdelvlaygisdtnephaqwqfssdipktiaeyfqatsgvypkkygqsyyacsqkvsqgidytrfasmldniindyklifnsgksvippmsktesycledalndlfipettietilkrltikkniilqgppgvgktfvarrlaylltgekapqrvnmvqfhqsysyedfiqgyrpngvgfrrkdgifynfcqqakeqpekkyifiideinranlskvfgevmmlmehdkrgenwsvpltysendeerfyvpenvyiiglmntadrslavvdyalrrrfsfidiepgfdtpqfrnfllnkkaepsfveslcqkmnelnqeiskeatilgkgfrighsyfccgledgtspdtqwlneivmtdiaplleeyffddpykqqkwtnkllgds]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mcrB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=mcrB]]&nbsp;&nbsp;


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McrB-S is an alternative product initiating at codon 162.  McrB-S is seen in some overexpression constructs but has not yet been observed as a native protein.  McrB-S has no known function.<ref name='LIB:EcoGene'/>
McrB-S is an alternative product initiating at codon 162.  McrB-S is seen in some overexpression constructs but has not yet been observed as a native protein.  McrB-S has no known function.<ref name='LIB:EcoGene'/>


In vitro, purified McrBs modulates the cleavage activity of McrBC, probably through binding to McrC.<ref name='PMID:9736625'/>,


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==References==
==References==
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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

mcrB

Gene Synonym(s)

ECK4336, b4346, JW5871, rglB[1], rglB

Product Desc.

McrB subunit of 5-methylcytosine restriction system[2][3];

Component of McrBC restriction endonuclease[3]

McrBC restriction endonuclease, catalytic subunit; 5-methylcytosine-specific; requires GTP, inhibited by ATP[4]

Product Synonyms(s)

5-methylcytosine-specific restriction enzyme McrBC, subunit McrB[1], B4346[2][1], RglB[2][1], McrB[2][1] , ECK4336, JW5871, rglB, b4346

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mcrBC[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


McrB-S is an alternative product initiating at codon 162. McrB-S is seen in some overexpression constructs but has not yet been observed as a native protein. McrB-S has no known function.[4]

In vitro, purified McrBs modulates the cleavage activity of McrBC, probably through binding to McrC.[5],


References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ Panne, D et al. (1998) McrBs, a modulator peptide for McrBC activity. EMBO J. 17 5477-83 PubMed
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