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{{Tab On|Quickview|mrcB}}{{Tab|Gene|mrcB}}{{Tab|Gene Product(s)|mrcB}}{{Tab|Expression|mrcB}}{{Tab|Evolution|mrcB}}{{Tab|On One Page|mrcB}}{{TabsBottom}}
{{Tab On|Quickview|mrcB}}{{Tab|Gene|mrcB}}{{Tab|Gene Product(s)|mrcB}}{{Tab|Expression|mrcB}}{{Tab|Evolution|mrcB}}{{Tab|On One Page|mrcB}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[mrcB:Gene|''mrcB]]'' (synonyms: ''ECK0148, b0149, JW0145, pbpF, ponB'')<ref name='LIB:Riley_2006'/>
''mrcB''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[mrcB:Gene_Product(s)|MrcB product]]<ref name='LIB:Riley_2006'/>: fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/>, PonB<ref name='LIB:EcoCyc10.6'/>, PbpF<ref name='LIB:EcoCyc10.6'/>, MrcB<ref name='LIB:EcoCyc10.6'/>, PBP1B<ref name='LIB:EcoCyc10.6'/>, [[:Category:Complex:penicillin-binding protein 1B|penicillin-binding protein 1B]]<ref name='LIB:EcoCyc11.1'/>
''ECK0148, b0149, JW0145, pbpF, ponB''<ref name='LIB:Riley_2006'/>, ponB''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:penicillin-binding protein 1B|penicillin-binding protein 1B]]<ref name='LIB:EcoCyc11.1'/>


Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''fused glycosyl transferase<ref name='LIB:Riley_2006'/>, transpeptidase<ref name='LIB:Riley_2006'/>, B0149<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PonB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PbpF<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MrcB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PBP1B<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0148, JW0145, pbpF, ponB, b0149''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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|-
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:mrcB|mrcB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mrcB|mrcB]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=mrcB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10605]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000598&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=mrcB&loc=MG1655%3A164730..167264,W3110%3A164730..167264,DH10B%3A138834..141368,REL606%3A167581..170106,BW2952%3A164729..167263]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=164729&end=167263&gene=mrcB&aa=magndrepigrkgkptrpvkqkvsrrryeddddyddyddyedeepmprkgkgkgkgrkprgkrgwlwlllklaivfavliaiygvyldqkirsridgkvwqlpaavygrmvnlepdmtisknemvklleatqyrqvskmtrpgeftvqansiemirrpfdfpdskegqvrarltfdgdhlativnmennrqfgffrldprlitmisspngeqrlfvprsgfpdllvdtllatedrhfyehdgislysigravlanltagrtvqgastltqqlvknlflssersywrkaneaymalimdaryskdrilelymnevylgqsgdneirgfplaslyyfgrpveelsldqqallvgmvkgasiynpwrnpklalerrnlvlrllqqqqiidqelydmlsarplgvqprggvispqpafmqlvrqelqaklgdkvkdlsgvkifttfdsvaqdaaekaavegipalkkqrklsdletaivvvdrfsgevramvggsepqfagynramqarrsigslakpatyltalsqpkiyrlntwiadapialrqpngqvwspqnddrrysesgrvmlvdaltrsmnvptvnlgmalglpavtetwiklgvpkdqlhpvpamllgalnltpievaqafqtiasggnraplsalrsviaedgkvlyqsfpqaeravpaqaayltlwtmqqvvqrgtgrqlgakypnlhlagktgttnnnvdtwfagidgstvtitwvgrdnnqptklygasgamsiyqrylanqtptplnlvppediadmgvdydgnfvcsggmrilpvwtsdpqslcqqsemqqqpsgnpfdqssqpqqqpqqqpaqqeqkdsdgvagwikdmfgsn]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mrcB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=mrcB]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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Latest revision as of 21:47, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

mrcB

Gene Synonym(s)

ECK0148, b0149, JW0145, pbpF, ponB[1], ponB

Product Desc.

MrcB[2][3];

Component of penicillin-binding protein 1B[3]

Murein polymerase, PBP1B; bifunctional murein transglycosylase and transpeptidase; penicillin-binding protein 1B; dimeric[4]

Product Synonyms(s)

fused glycosyl transferase[1], transpeptidase[1], B0149[2][1], PonB[2][1], PbpF[2][1], MrcB[2][1], PBP1B[2][1] , ECK0148, JW0145, pbpF, ponB, b0149

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mrcB[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


MrcB is part of a complex with MltA and MipA. The N-terminal transglycosylase activity polymerizes the glycan backbone and is penicillin-insensitive. The C-terminal transpeptidase activity crosslinks the muramic peptides and is penicillin-sensitive. Full length MrcB is the alpha isoform. A second in vivo ATG start at codon 46 produces the 799 aa gamma isoform. Murein polymerase is an essential function satisfied by either MrcA or MrcB. Mutants have elevated OM vesiculation (McBroom, 2006). MrcB is a membrane-bound periplasmic enzyme that has an uncleaved signal anchor.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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