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{{Tab On|Quickview|fis}}{{Tab|Gene|fis}}{{Tab|Gene Product(s)|fis}}{{Tab|Expression|fis}}{{Tab|Evolution|fis}}{{Tab|On One Page|fis}}{{TabsBottom}}
{{Tab On|Quickview|fis}}{{Tab|Gene|fis}}{{Tab|Gene Product(s)|fis}}{{Tab|Expression|fis}}{{Tab|Evolution|fis}}{{Tab|On One Page|fis}}{{TabsBottom}}
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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[fis:Gene|''fis]]'' (synonyms: ''ECK3248, b3261, JW3229, nbp'')<ref name='LIB:Riley_2006'/>
''fis''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[fis:Gene_Product(s)|Fis product]]<ref name='LIB:Riley_2006'/>: global DNA-binding transcriptional dual regulator<ref name='LIB:Riley_2006'/>, B3261<ref name='LIB:EcoCyc10.6'/>, Nbp<ref name='LIB:EcoCyc10.6'/>, Fis<ref name='LIB:EcoCyc10.6'/>, site-specific DNA inversion stimulation factor; DNA-binding protein; a trans activator for transcription<ref name='LIB:EcoCyc10.6'/>
''ECK3248, b3261, JW3229, nbp''<ref name='LIB:Riley_2006'/>, nbp''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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Fis transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
Fis transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


 
Transcriptional activator for rRNA operons, bends DNA; interacts with RNAP; nucleoid-associated protein; dimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''global DNA-binding transcriptional dual regulator<ref name='LIB:Riley_2006'/>, B3261<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Nbp<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fis<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, site-specific DNA inversion stimulation factor; DNA-binding protein; a trans activator for transcription<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3248, JW3229, nbp, b3261''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:txn_units:dusB-fis|dusB-fis]]<ref name='LIB:EcoCyc10.6'/>, OP00028, fis, yhdG-fis  
transcription unit(s): [[:Category:Txn_unit:dusB-fis|dusB-fis]]<ref name='LIB:EcoCyc10.6'/>, OP00028, fis, yhdG-fis  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=fis&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10317]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120000311&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=fis&loc=MG1655%3A3409293..3409589,W3110%3A3411126..3411422,DH10B%3A3507038..3507334,REL606%3A3339162..3339458,BW2952%3A3296441..3296737]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3296441&end=3296737&gene=fis&aa=mfeqrvnsdvltvstvnsqdqvtqkplrdsvkqalknyfaqlngqdvndlyelvlaeveqplldmvmqytrgnqtraalmmginrgtlrkklkkygmn]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=fis+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=fis]]&nbsp;&nbsp;
 
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==Notes==
===Notes===
{{BacktoTop}}
 
fis transcription is supercoiling-dependent.  Overexpression causes filamentous biofilm formation.  Decreased levels of Fis inhibit open complex formation, inhibiting oriC unwinding by blocking IHF and DnaA low affinity binding sites. Polyamine modulon. Mutations affect chromosomal supercoliing.<ref name='LIB:EcoGene'/>
 




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==References==
==References==
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<references/>
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Latest revision as of 21:50, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

fis

Gene Synonym(s)

ECK3248, b3261, JW3229, nbp[1], nbp

Product Desc.

Fis transcriptional dual regulator[2][3]

Transcriptional activator for rRNA operons, bends DNA; interacts with RNAP; nucleoid-associated protein; dimeric[4]

Product Synonyms(s)

global DNA-binding transcriptional dual regulator[1], B3261[2][1], Nbp[2][1], Fis[2][1], site-specific DNA inversion stimulation factor; DNA-binding protein; a trans activator for transcription[2][1] , ECK3248, JW3229, nbp, b3261

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): dusB-fis[2], OP00028, fis, yhdG-fis

Regulation/Activity
Quick Links



        

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


fis transcription is supercoiling-dependent. Overexpression causes filamentous biofilm formation. Decreased levels of Fis inhibit open complex formation, inhibiting oriC unwinding by blocking IHF and DnaA low affinity binding sites. Polyamine modulon. Mutations affect chromosomal supercoliing.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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