seqA:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[seqA:Gene|''seqA]]'' (synonyms: ''ECK0675, b0687, JW0674'')<ref name='LIB:Riley_2006'/>
''seqA''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[seqA:Gene_Product(s)|SeqA product]]<ref name='LIB:Riley_2006'/>: regulatory protein for replication initiation product, B0687 product
''ECK0675, b0687, JW0674''<ref name='LIB:Riley_2006'/>, JW0674''
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
SeqA, negative modulator of initiation of replication<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''regulatory protein for replication initiation<ref name='LIB:Riley_2006'/>, B0687<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, SeqA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0675, JW0674, b0687''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:seqA-pgm|seqA-pgm]]<ref name='LIB:EcoCyc10.6'/>  
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|-
!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=seqA&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG12197]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120002086&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=seqA&loc=MG1655%3A712210..712755,W3110%3A713409..713954,DH10B%3A764802..765347,REL606%3A695082..695627,BW2952%3A614970..615515]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=614970&end=615515&gene=seqA&aa=mktievddelysyiashtkhigesasdilrrmlkfsaasqpaapvtkevrvaspaiveakpvktikdkvramrelllsdeyaeqkravnrfmlllstlysldaqafaeateslhgrtrvyfaadeqtllkngnqtkpkhvpgtpywvitntntgrkcsmiehimqsmqfpaeliekvcgti]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=seqA+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=seqA]]&nbsp;&nbsp;


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Latest revision as of 21:55, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

seqA

Gene Synonym(s)

ECK0675, b0687, JW0674[1], JW0674

Product Desc.

SeqA, negative modulator of initiation of replication[2][3]

Sequesters newly replicated hemimethylated oriC origins to prevent re-initiation; binds hemimethylated GATC sequences; SeqA foci required for chromosome segregation; binds and stimulates Topo IV[4]

Product Synonyms(s)

regulatory protein for replication initiation[1], B0687[2][1], SeqA[2][1] , ECK0675, JW0674, b0687

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): seqA-pgm[2]

Regulation/Activity
Quick Links



        

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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


SeqA is required for the membrane binding of hemimethylated oriC in vitro. SeqA may facilitate cII binding to phage lambda promoters, enhancing transcription. SeqA self-association function is in the N-terminal domain. DNA-binding activity is in C-terminal domain. SeqA expression is negatively modulated by HU. SeqA is a homotetramer. aphA(hobH) mutants overproduce SeqA.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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