argK:Quickview: Difference between revisions

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{|   id="B49aee03614b13" class=" tableEdit New_Quickview_Table"


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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[argK:Gene|''argK]]'' (synonyms: ''ECK2914, b2918, JW2885, ygfD'')<ref name='LIB:Riley_2006'/>
''argK''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[argK:Gene_Product(s)|ArgK product]]<ref name='LIB:Riley_2006'/>: membrane ATPase/protein kinase product, B2918 product, YgfD product
''ECK2914, b2918, JW2885, ygfD''<ref name='LIB:Riley_2006'/>, meaB, scpK?, ygfD''
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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arginine transport ATPase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
arginine transport ATPase<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


Required to convert succinate to propionate, Arg transport?; reported to have ATPase and protein kinase activity<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''membrane ATPase/protein kinase<ref name='LIB:Riley_2006'/>, B2918<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, YgfD<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, ArgK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK2914, JW2885, meaB, scpK?, ygfD, b2918''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:scpA-argK-ygfGH|scpA-argK-ygfGH]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:scpA-argK-ygfGH|scpA-argK-ygfGH]]<ref name='LIB:EcoCyc10.6'/>  
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=argK&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11445]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001409&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=argK&loc=MG1655%3A3061009..3062004,W3110%3A3061643..3062638,DH10B%3A3154879..3155874,REL606%3A2948738..2949733,BW2952%3A2948157..2949152]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=2948157&end=2949152&gene=argK&aa=mineatlaesirrlrqgeratlaqamtlvesrhprhqalstqlldaimpycgntlrlgvtgtpgagkstfleafgmllireglkvaviavdpsspvtggsilgdktrmndlaraeaafirpvpssghlggasqrarelmllceaagydvvivetvgvgqsetevarmvdcfislqiagggddlqgikkglmevadlivinkddgdnhtnvaiarhmyesalhilrrkydewqprvltcsalekrgideiwhaiidfktaltasgrlqqvrqqqsvewlrkqteeevlnhlfanedfdryyrqtllavknntlsprtglrqlsefiqtqyfd]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=argK+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=argK]]&nbsp;&nbsp;


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{{Quickview_table_help}}
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===Notes===
===Notes===
{{BacktoTop}}
{{BacktoTop}}
The role of ArgK in arginine transport needs to be reexamined.  Characterization of the ArgK ortholog MeaB strongly suggests that ArgK is actually involved in protecting Mcm from inactivation and that ArgK may bind to Mcm. MeaB and Mcm are fused in some organisms. MeaB of M. extorquens binds and hydrolyzes GTP. ArgK is a homolog of the human disease gene MMAA, implicated in methylmalonic aciduria.  Part of a four gene operon encoding enzymes converting succinate to propionate. ATPase, but not protein kinase, activity is reportedly required for arginine transport. ArgK does not have predicted transmembrane segments typical of a membrane protein.<ref name='LIB:EcoGene'/>




Latest revision as of 21:53, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

argK

Gene Synonym(s)

ECK2914, b2918, JW2885, ygfD[1], meaB, scpK?, ygfD

Product Desc.

arginine transport ATPase[2][3]

Required to convert succinate to propionate, Arg transport?; reported to have ATPase and protein kinase activity[4]

Product Synonyms(s)

membrane ATPase/protein kinase[1], B2918[2][1], YgfD[2][1], ArgK[2][1] , ECK2914, JW2885, meaB, scpK?, ygfD, b2918

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): scpA-argK-ygfGH[2]

Regulation/Activity
Quick Links



        

edit table

See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


The role of ArgK in arginine transport needs to be reexamined. Characterization of the ArgK ortholog MeaB strongly suggests that ArgK is actually involved in protecting Mcm from inactivation and that ArgK may bind to Mcm. MeaB and Mcm are fused in some organisms. MeaB of M. extorquens binds and hydrolyzes GTP. ArgK is a homolog of the human disease gene MMAA, implicated in methylmalonic aciduria. Part of a four gene operon encoding enzymes converting succinate to propionate. ATPase, but not protein kinase, activity is reportedly required for arginine transport. ArgK does not have predicted transmembrane segments typical of a membrane protein.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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