folK:Quickview: Difference between revisions

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!{{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[folK:Gene|''folK]]'' (synonyms: ''ECK0141, b0142, JW0138'')<ref name='LIB:Riley_2006'/>
''folK''
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!{{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[folK:Gene_Product(s)|FolK product]]<ref name='LIB:Riley_2006'/>: 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase product, HPPK product, B0142 product
''ECK0141, b0142, JW0138''<ref name='LIB:Riley_2006'/>, JW0138''
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!{{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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H2PTERIDINEPYROPHOSPHOKIN-MONOMER<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
H2PTERIDINEPYROPHOSPHOKIN<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Product Synonyms(s)
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''2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase<ref name='LIB:Riley_2006'/>, HPPK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, B0142<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, FolK<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK0141, JW0138, b0142''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!{{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Knock-Out Phenotype
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!{{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:pcnB-folK|pcnB-folK]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:pcnB-folK|pcnB-folK]]<ref name='LIB:EcoCyc10.6'/>  
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!{{table_heading_style}} |Regulation/Activity
!align=left {{table_heading_style}} |Regulation/Activity
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!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=folK&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11374]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120001342&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=folK&loc=MG1655%3A157732..157253,W3110%3A157732..157253,DH10B%3A131836..131357,REL606%3A160583..160104,BW2952%3A157252..157731]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=157252&end=157731&gene=folK&aa=mtvayiaigsnlaspleqvnaalkalgdipeshiltvssfyrtpplgpqdqpdylnaavaletslapeellnhtqrielqqgrvrkaerwgprtldldimlfgnevinterltvphydmknrgfmlwplfeiapelvfpdgemlrqilhtrafdklnkw]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=folK+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=folK]]&nbsp;&nbsp;
 
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===Notes===
===Notes===
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HPPK active center is formed once both substrates,  ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide.  Catalytic loop 3  is involved in ternary complex stabilization and is necessary for catalysis.<ref name='LIB:EcoGene'/>




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==References==
==References==
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Latest revision as of 21:50, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

folK

Gene Synonym(s)

ECK0141, b0142, JW0138[1], JW0138

Product Desc.

H2PTERIDINEPYROPHOSPHOKIN[2][3]

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase; monomeric[4]

Product Synonyms(s)

2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase[1], HPPK[2][1], B0142[2][1], FolK[2][1] , ECK0141, JW0138, b0142

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): pcnB-folK[2]

Regulation/Activity
Quick Links



        

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Notes

[back to top]


HPPK active center is formed once both substrates, ATP and HP, are bound and this assembly results in confirmational changes primarily in catalytic loops 1-3; catalytic loop 3 moves in the opposite direction upon binding of the nucleotide. Catalytic loop 3 is involved in ternary complex stabilization and is necessary for catalysis.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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