mdaB:Quickview: Difference between revisions

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!align=left {{table_heading_style}} |Gene Name
!align=left {{table_heading_style}} |Standard Name
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[[mdaB:Gene|''mdaB]]'' (synonyms: ''ECK3019, b3028, JW2996, mda66'')<ref name='LIB:Riley_2006'/>
''mdaB''
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!align=left {{table_heading_style}} |Product(s)  
!align=left {{table_heading_style}} |Gene Synonym(s)
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[[mdaB:Gene_Product(s)|MdaB product]]<ref name='LIB:Riley_2006'/>: NADPH quinone reductase product, B3028 product
''ECK3019, b3028, JW2996, mda66''<ref name='LIB:Riley_2006'/>, mda66''
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!align=left {{table_heading_style}} |Description
!align=left {{table_heading_style}} |Product Desc.
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EG12656-MONOMER<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>  
EG12656<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>;


Component of [[:Category:Complex:NADPH quinone reductase|NADPH quinone reductase]]<ref name='LIB:EcoCyc11.1'/>
Component of [[:Category:Complex:quinone reductase|quinone reductase]]<ref name='LIB:EcoCyc11.1'/>


FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric<ref name='LIB:EcoGene'/>
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!align=left {{table_heading_style}} |Knock-Out Phenotype
!align=left {{table_heading_style}} |Product Synonyms(s)
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''NADPH quinone reductase<ref name='LIB:Riley_2006'/>, B3028<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MdaB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3019, JW2996, mda66, b3028''
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!align=left {{table_heading_style}} |Function from GO
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<GO_nr />
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!align=left {{table_heading_style}} |Knock-Out Phenotype
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!align=left {{table_heading_style}} |Regulation/Expression
!align=left {{table_heading_style}} |Regulation/Expression
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transcription unit(s): [[:Category:Txn_unit:mdaB|mdaB]]<ref name='LIB:EcoCyc10.6'/>  
transcription unit(s): [[:Category:Txn_unit:mdaB|mdaB]]<ref name='LIB:EcoCyc10.6'/>  
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|-
!align=left {{table_heading_style}} |Quick Links
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[[File:porteco.png|link=http://porteco.org/AjaxSearch.jsp?searchString=mdaB&s=search]] [[File:EcoCyc.gif|link=http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG12656]] [[File:regulondb.jpg|link=http://regulondb.ccg.unam.mx/gene?term=ECK120002346&organism=ECK12&format=jsp&type=gene ]] <br/><br/> [[File:dnadisplay.png|link=http://ecoliwiki.net/tools/display_dna.php?gene=mdaB&loc=MG1655%3A3170552..3171133,W3110%3A3171186..3171767,REL606%3A3106702..3107283,DH10B%3A3268297..3268878,BW2952%3A3057700..3058281]] [[File:proteindisplay.png|link=http://ecoliwiki.net/tools/display_protein.php?f=NC_000913&start=3057700&end=3058281&gene=mdaB&aa=msniliingakkfahsngqlndtltevadgtlrdlghdvrivradsdydvkaevqnflwadvviwqmpgwwmgapwtvkkyiddvfteghgtlyasdgrtrkdpskkygsgglvqgkkymlsltwnapmeaftekdqffhgvgvdgvylpfhkanqflgmeplptfiandvikmpdvpryteeyrkhlveifg]]&nbsp;&nbsp;  [[File:pubmed.jpg|link=http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=Search&Term=mdaB+AND+escherichia+coli]]&nbsp;&nbsp;  [[File:textpresso.jpg|link=http://textpresso.tamu.edu/cgi-bin/textpresso/search?q=mdaB]]&nbsp;&nbsp;


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Latest revision as of 21:48, 27 May 2013

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions
Standard Name

mdaB

Gene Synonym(s)

ECK3019, b3028, JW2996, mda66[1], mda66

Product Desc.

EG12656[2][3];

Component of quinone reductase[3]

FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric[4]

Product Synonyms(s)

NADPH quinone reductase[1], B3028[2][1], MdaB[2][1] , ECK3019, JW2996, mda66, b3028

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): mdaB[2]

Regulation/Activity
Quick Links



        

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See Help:Quickview for help with entering information in the Quickview table.

Notes

[back to top]


MdaB overexpression results in resistance to cytotoxic drugs including adriamycin, etoposide and the tumoricidal agent DMP 840. Induced 25-fold by 2-methylene-4-butyrolactone and 2-methyl-1,4-naphthoquinone (menadione). mdaB is in an operon with ygiN. Reduces menadione to menadiol. May have some nitroreductase activity. Paradoxically also reported to be NADPH-specific.[4]



References

[back to top]


  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
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