View source for Phage T4

Bacteriophage T4 is a member of the [http://www.ictvonline.org/virusTaxonomy.asp?bhcp=1 ICTV] family [[:Category:Myoviridae|myoviridae]], long-tailed viruses with contractile tails.  T4 is the namesake of the T4-like virus genus.  T4 and its relatives were used for many of the key experiments in the history of molecular biology.

== Morphology ==

== Genome Organization ==
T4 has a circular genetic map<ref name='PMID:14172990'/>, but the T4 genome is physically packaged as linear dsDNA.  Headful packaging incorporates DNA that is circularly permuted<ref name='PMID:14130440'/> and terminally redundant<ref name='PMID:4222403'/> with respect to the genetic map.

== Life cycle ==
=== Lytic cycle ===
==== Adsorbtion and Injection ====

==== Early gene expression ====

==== Middle gene expression ====

==== DNA replication ====
Initiation of DNA replication has been reviewed by Kreuzer and Brister<ref name='PMID:21129203'/> and ''many references needed''.  Replication starts early in infection from multiple origins and then shifts to a recombination-dependent phase.

T4 replisomes have been intensely studied, and work from the Alberts lab led to the "trombone model" for coupling of leading and lagging strand progression.  High resolution structures for part or all of several replisome proteins have been determined (reviewed by Mueser et al. <ref name='PMID: 21129204'/>)

==== Late gene expression ====

==== Packaging ====

==== Lysis ====

== Other phenomena of interest ==
=== intron homing ===

=== base modification ===

=== lysis inhibition ===

=== exclusion ===

== See also ==
* [[:Category:Gene_List:Phage_T4|List of T4 gene pages in EcoliWiki]]
* [http://phage.ggc.edu/ GGC T4-like Genome website!]
* [http://www.oercommons.org/libraries/bacteriophage-t4/view Computer animation of T4 infection]
* [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10665&lvl=3&lin=f&keep=1&srchmode=1&unlock Phage T4 Taxonomy on NCBI]
* [http://ictvdb.org/ICTVdB/02.043.0.01.htm International Committee on Taxonomy of Viruses]
* [http://www.ncbi.nlm.nih.gov/nuccore/NC_000866.4 NC 000866.4 on NCBI]
* [http://www.ncbi.nlm.nih.gov/nuccore/AF158101.6 GenBank record for T4]
* [[wikipedia:Enterobacteria_phage_T4| T4 in Wikipedia]]

== References ==
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<references/>

[[Category:T4-like]]