yafQ:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
yafQ |
|---|---|
| Gene Synonym(s) |
ECK0226, b0225, JW0215[1], JW0215 |
| Product Desc. |
predicted toxin of the YafQ-DinJ toxin-antitoxin system[2]; toxin of the YafQ-DinJ toxin-antitoxin system[3] Toxin of TA pair YafQ/DinJ, inhibitor of translation[4] |
| Product Synonyms(s) |
predicted toxin of the YafQ-DinJ toxin-antitoxin system[1], B0225[2][1], YafQ[2][1] , ECK0226, JW0215, b0225 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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Notes
YafQ is homologous to the RelE toxin, which inhibits translation as a sequence-specific mRNA endoribonuclease. Coexpression of DinJ with YafQ blocks the growth inhibitory effect of YafQ (Motiejunaite, 2007; Szekeres, 2007). YafQ overexpression does not inhibit rich media growth completely (but does block growth on M9 glycerol plates) or cause a loss in CFU, as do the other toxins (Motiejunaite, 2007). DinJ and YafQ form a complex (Motiejunaite, 2007).[4] YafQ associates with ribosomes and stimulates mRNA cleavage at the A site[5]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ Prysak, MH et al. (2009) Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage. Mol. Microbiol. 71 1071-87 PubMed
