sdiA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
sdiA |
|---|---|
| Gene Synonym(s) |
ECK1915, b1916, JW1901, uvrX[1], uvrX |
| Product Desc. |
SdiA transcriptional activator[2]; SdiA transcriptional dual regulator[3] Quorum-sensing ftsQAZ-P2, acrABCDE transcriptional activator; fluoroquinolone resistance; overproduction confers drug resistance by stimulating the acr genes; SdiA senses exogenous N-acyl homoserine lactones[4] |
| Product Synonyms(s) |
DNA-binding transcriptional activator[1], B1916[2][1], SdiA[2][1] , ECK1915, JW1901, uvrX, b1916 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
Suppresses inhibitory effect of the MinC/MinD division inhibitor. N-acyl homoserine lactones act as folding switches for SdiA. LuxR family. SdiA has other global transcription targets such as uvrY, csrB, recN and nei. E. coli makes an unknown weak auto-inducer when grown in rich media. Most phenotypic effects require overproduction of SdiA. sdiA mutants are more sensitive to fluoroquinolones and have reduced AcrB protein, but are not defective in cell division. An sdiA ydiV double mutant has twofold reduced cAMP levels than inhibits quorum sensing system 2 (Zhou, 2008).[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
