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References Suggestions


Standard Name


Gene Synonym(s)

ECK0378, b0383, JW0374, psiA[1], psiA

Product Desc.


Component of alkaline phosphatase[2][3]

Alkaline phosphatase, periplasmic; binds Zn(II); dimeric[4]

Product Synonyms(s)

bacterial alkaline phosphatase[1], B0383[2][1], PsiA[2][1], PhoA[2][1] , ECK0378, JW0374, psiA, b0383

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): phoA-psiF[2], OP00071, phoA

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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Arg22 is removed from the mature enzyme by Iap to form isozyme 3. Isozyme 2 is a heterodimer of isozymes 1 and 3 subunits. PhoA requires the reducing environment of the periplasm and DsbA for activity; cysteine bonds C190-C200 and C308-C358 are needed. PhoA fusions are used to indicate periplasmic location of hybrid proteins.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.