nfsA:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
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| Standard Name |
nfsA |
|---|---|
| Gene Synonym(s) |
ECK0842, b0851, JW0835, mdaA, ybjB, mda18[1], mda18, snrA |
| Product Desc. |
Component of nitroreductase[3] Nitroreductase A; oxygen-insensitive, NADPH, FMN-dependent, major; reduces a variety of nitroaromatics, e.g. dihydropteridine, nitrofurantoin, nitrofurazone, quinones; SoxS regulon; homodimeric[4] |
| Product Synonyms(s) |
nitroreductase A, NADPH-dependent, FMN-dependent[1], B0851[2][1], YbjB[2][1], NfsA[2][1], MdaA[2][1] , ECK0842, JW0835, mda18, mdaA, snrA, ybjB, b0851 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression |
transcription unit(s): ybjC-nfsA-rimK-ybjN[2] |
| Regulation/Activity | |
| Quick Links |
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Notes
NfsA overexpression results in resistance to cytotoxic drugs includingAdriamycin and the tumoricidal agent DMP 840. nfsA is co-transcribed with ybjC. nfsA, nfsB, rutE, and ydjA are paralogs.[4]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
