melR:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
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Standard Name

melR

Gene Synonym(s)

ECK4111, b4118, JW4079[1], JW4079

Product Desc.

MelR transcriptional dual regulator[2][3]

Transcriptional activator for melAB, AraC family; autoregulatory repressor in absence of co-activator melibiose[4]

Product Synonyms(s)

DNA-binding transcriptional dual regulator[1], B4118[2][1], MelR[2][1], regulator of melibiose operon[2][1] , ECK4111, JW4079, b4118

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): melR[2], OP00050

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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The C-terminal domain of the RNA polymerase alpha subunit is important for MelR-dependent activation of the melAB promoter. An 18 base pair MelR binding site is necessary for MelR transcription activation because it ensures correct interactions with RNA polymerase sigma subunit.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.