mdaB:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
mdaB |
|---|---|
| Gene Synonym(s) |
ECK3019, b3028, JW2996, mda66[1], mda66 |
| Product Desc. |
Component of quinone reductase[3] FMN-dependent NADH-quinone reductase; MdaB and YgiN form an enzymatic quinone reduction-oxidation cycle in vitro; possibly mitigates toxicity of quinols and quinones in vivo; dimeric[4] |
| Product Synonyms(s) |
NADPH quinone reductase[1], B3028[2][1], MdaB[2][1] , ECK3019, JW2996, mda66, b3028 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype | |
| Regulation/Expression | |
| Regulation/Activity | |
| Quick Links |
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| edit table |
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Notes
MdaB overexpression results in resistance to cytotoxic drugs including adriamycin, etoposide and the tumoricidal agent DMP 840. Induced 25-fold by 2-methylene-4-butyrolactone and 2-methyl-1,4-naphthoquinone (menadione). mdaB is in an operon with ygiN. Reduces menadione to menadiol. May have some nitroreductase activity. Paradoxically also reported to be NADPH-specific.[4]
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
