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Lambda repressor N-terminal domain/operator cocrystal PDB:1LMB
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The structure of the N-terminal domain of lambda repressor in a cocrystal with operator DNA was described by Beamer and Pabo[1]. DNA recognition is via a helix-turn-helix DNA binding motif <jmol>
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</jmol>that contacts operator DNA in the major groove. Additonal contacts are made by an N-terminal arm <jmol>
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</jmol>that reaches around the DNA.
The N-terminal domain forms weak homodimers via helix 5-helix 5 contacts <jmol>
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References
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- ↑ Beamer, LJ & Pabo, CO (1992) Refined 1.8 A crystal structure of the lambda repressor-operator complex. J. Mol. Biol. 227 177-96 PubMed
- ↑ Reidhaar-Olson, JF & Sauer, RT (1988) Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences. Science 241 53-7 PubMed
