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References Suggestions


Standard Name


Gene Synonym(s)

ECK3322, b3335, JW3297, yheC, hofD, hopO, hopD[1], hopD

Product Desc.

leader peptidase, integral membrane protein[2][3];

Component of GspC-O secreton complex[3]

Prepilin peptidase in H-NS-silenced gsp divergon; type II protein secretion; cloned gsp divergon secretes ChiA[4]

Product Synonyms(s)

bifunctional prepilin leader peptidase and methylase[1], B3335[2][1], YheC[2][1], HopO[2][1], HopD[2][1], GspO[2][1], HofD[2][1] , ECK3322, hofD, hopD, hopO, JW3297, yheC, b3335

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): gspC[2][3]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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GspG is processed by GspO when both are expressed. gspO complements a pulO mutation for pullanase secretion in a K-12 strain with the Klebsiella pul operon. GspO cleaves PilE (N. gonorrhoeae) and PulG (K.oxytoca). A divergon is a regulon comprised of two adjacent divergent operons or genes.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.