From EcoliWiki
(Redirected from cusF)
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions


Standard Name


Gene Synonym(s)

ECK0565, b0573, JW0562, cusX, ylcC[1], silF, ylcC

Product Desc.

periplasmic copper-binding protein[2][3];

Component of Copper Transporting Efflux System[3]

Silver and copper efflux, periplasmic binding protein; metallochaperone; confers copper and silver resistance; CusF binds both Cu(I) and Ag(I) with high affinity, but does not bind Cu(II)[4]

Product Synonyms(s)

periplasmic copper-binding protein[1], B0573[2][1], CusX[2][1], CusF[2][1], YlcC[2][1], ORF110[2][1], agrF[2][1] , cusX, ECK0565, JW0562, silF, ylcC, b0573

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): cusCFBA[2], ylcBCD-ybdE

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>


[back to top]

cusF is in the cusCFBA Cu/Ag efflux operon regulated by Cu and Ag. The first 22 aa are predicted to be a type I signal peptide. However, N-terminal sequencing revealed cleavage after residue 21; the CusF clone construct had eight additional amino acids added at the N-terminus (Fanake, 2003). The cleavage specificity may have been altered by the additional amino acids or the prediction is incorrect.[4]


[back to top]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.