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References Suggestions


Standard Name


Gene Synonym(s)

ECK3310, b3323, JW3285, yheD[1], yheD

Product Desc.

general secretory pathway component, cryptic[2][3]

Part of H-NS-silenced gsp divergon, type II protein secretion; cloned gsp divergon secretes ChiA, requires gspAB operon[4]

Product Synonyms(s)

general secretory pathway component, cryptic[1], B3323[2][1], YheD[2][1], GspA[2][1] , ECK3310, JW3285, yheD, b3323

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): pioO[2], gspA-pioO[2], gspAB[3]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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GspA is homologous to exeA of A. hydrophila, which is required for protein export, specifically for the export and assembly of secretin (ExeD/GspD) into the outer membrane. GspA has an N-terminal predicted cytoplasmic domain with an ATP/GTP binding motif, a single predicted transmembrane segment (239-261), followed by a predicted periplasmic domain with a predicted C-terminal peptidoglycan-binding motif (407-467; Pfam PG_binding_1). GspA may interact with GspB. A divergon is a regulon comprised of two adjacent divergent operons or genes. Overexpression causes a decrease in the amount of biofilm formed and decreases motility.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.