argK:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

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Standard Name

argK

Gene Synonym(s)

ECK2914, b2918, JW2885, ygfD[1], meaB, scpK?, ygfD

Product Desc.

arginine transport ATPase[2][3]

Required to convert succinate to propionate, Arg transport?; reported to have ATPase and protein kinase activity[4]

Product Synonyms(s)

membrane ATPase/protein kinase[1], B2918[2][1], YgfD[2][1], ArgK[2][1] , ECK2914, JW2885, meaB, scpK?, ygfD, b2918

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression

transcription unit(s): scpA-argK-ygfGH[2]

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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The role of ArgK in arginine transport needs to be reexamined. Characterization of the ArgK ortholog MeaB strongly suggests that ArgK is actually involved in protecting Mcm from inactivation and that ArgK may bind to Mcm. MeaB and Mcm are fused in some organisms. MeaB of M. extorquens binds and hydrolyzes GTP. ArgK is a homolog of the human disease gene MMAA, implicated in methylmalonic aciduria. Part of a four gene operon encoding enzymes converting succinate to propionate. ATPase, but not protein kinase, activity is reportedly required for arginine transport. ArgK does not have predicted transmembrane segments typical of a membrane protein.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.