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References Suggestions


Standard Name


Gene Synonym(s)

yqcD, ECK2789, b2794, JW2765[1][2], JW2765

Product Desc.

NADPH-dependent nitrile oxidoreductase[2][3];

Component of 7-cyano-7-deazaguanine reductase[3]

7-cyano-7-deazaguanine reductase (NADPH-dependent); converts preQ0 to preQ1, queuosine biosynthesis[4]

Product Synonyms(s)

conserved protein[1], B2794[2][1], YqcD[2][1], QueF[2][1] , ECK2789, JW2765, yqcD, b2794

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): yqcD[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Asn, Asp, Tyr, and His tRNA GUN anticodons are modified by queuosine at the G. The product of the QueF reaction is 7-aminomethyl-7-deazaguanine (preQ1). Activity demonstrated in vitro. tgt mutants lack queuosine and are have reduced survival in stationary phase. (Noguchi, 1982).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.