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References Suggestions


Standard Name


Gene Synonym(s)

ECK2577, b2579, JW2563[1], grcA, JW2563

Product Desc.

stress-induced alternate pyruvate formate-lyase subunit[2][3]

Autonomous glycine radical cofactor; can reactivate pyruvate formate lyase after oxidative stress; induced by low pH or propionate; pyruvate formate lyase homolog, "spare part" for PFL[4]

Product Synonyms(s)

pyruvate formate lyase subunit[1], B2579[2][1], YfiD[2][1] , ECK2577, grcA, JW2563, b2579

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): yfiD[2]

Quick Links


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A yfiD mutant excretes increased levels of organic acids when grown under oxygen-starved conditions. Radical activation mediated by PflA; deactivation not mediated by AdhE. Regulated by FNR, ArcA and PdhR. HT_Cmplx8_Cyt: YfiD+PflB. HT_Cmplx9_Cyt: YfiD+TdcE.[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.