From EcoliWiki
(Redirected from b2255)
Jump to: navigation, search

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions


Standard Name


Gene Synonym(s)

yfbG, ECK2248, b2255, JW2249, pmrI, SAF[1][2], pbgP3, SAF

Product Desc.


UDP-glucuronate dehydrogenase and UDP-ara4N formyltransferase[4]

Product Synonyms(s)

fused UDP-L-Ara4N formyltransferase[1], UDP-GlcA C-4'-decarboxylase[1], B2255[2][1], ArnA[2][1], YfbG[2][1], PmrI[2][1] , ECK2248, JW2249, pbgP3, pmrI, SAF, yfbG, b2255

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): yfbE[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>


[back to top]

Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. This bifunctional enzyme catalyzes two steps in lipid A phosphate group modification by aminoarabinose. The C-terminal 345-residues encode the NAD+-dependent dehydrogenase domain that catalyzes the first step in UDP-4-amino-4-deoxy-L-arabinose synthesis and involves successive C4 oxidation and C6 decarboxylation steps. The N-terminal 304-residue domain encodes N-10 formyltetrahydrofolate-dependent UDP-aminoarabinose N-formyltransferase (UDP-formamidoarabinose synthase) that makes the substrate for ArnC: UDP-ara4FN = uridine 5'-diphospho-beta-(4-deoxy-4-formamido-L-arabinose). ArnA is identical to ssrA-associated factor SAF. basRS regulon.[4]


[back to top]

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.