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References Suggestions


Standard Name


Gene Synonym(s)

ECK2054, b2060, JW2045[1], JW2045

Product Desc.

tyrosine kinase involved in colanic acid biosynthesis[2][3];

Component of capsular polysaccharide export apparatus[3]

Autophosphorylating protein tyrosine kinase Wzc, a regulator of capsule production; mutants do not make capsules; cognate with Wzb phosphatase; phosphorylates Ugd[4]

Product Synonyms(s)

protein-tyrosine kinase[1], B2060[2][1], Wzc[2][1] , ECK2054, JW2045, b2060

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): wza-wzb-wzc-wcaAB[2], OP00290, cps, cpsB, cpsGB

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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Wzc, but not Wzc-P, activates colanic acid synthesis, needed for capsule production. Wzc-P is dephosphorylated in vivo and in vitro by the Wzb phosphatase. Wzc-P is also dephosphorylated in vitro by the cryptic Etp phosphatase. Wzc has ATPAse activity (Soulat, 2007).[4]


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  1. 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.