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References Suggestions


Standard Name


Gene Synonym(s)

ECK0467, b0473, JW0462[1], JW0462

Product Desc.


Component of molecular chaperone, HSP90 family[3]

Heat shock chaperone, HSP90 family; has ATPase activity; binds RpoH; rpoH regulon; dimeric[4]

Product Synonyms(s)

molecular chaperone HSP90 family[1], B0473[2][1], HtpG[2][1], C62.5[2][1], Hsp90[2][1] , ECK0467, JW0462, b0473

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): htpG[2]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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HtpG undergoes substantial nucleotide-dependent conformational rearrangements (Huai, 2005; Shiau, 2006). HtpG can form heterodimers with human HSP90alpha. In vitro, HtpG transitions to oligomeric form at 65C, required for substrate solubilization. Binds TrxA (Kumar, 2004).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.