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References Suggestions


Standard Name


Gene Synonym(s)

ECK0444, b0450, JW0440, ybaI[1], ybaI

Product Desc.

[GlnK][2][3] , uridylyl-[GlnK][2][3]

Component of nitrogen regulatory protein GlnK[2][3]

Potent activator of NRII(GlnL/NtrB) phosphatase; trimeric; regulated through NRI/NRII two-component regulatory system; binds to membrane when inhibiting AmtB[4]

Product Synonyms(s)

nitrogen assimilation regulatory protein for GlnL, GlnE, and AmtB[1], B0450[2][1], YbaI[2][1],unmodified protein PII 2[2], modified protein PII 2[2][1],[protein PII2][2], uridylyl-[protein PII2][2][1],PII2[2], uridylyl-[PII2][2][1], , ECK0444, JW0440, ybaI, b0450

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): glnK-amtB[2]

Quick Links

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glnK is a glnB paralog. Like GlnB, the GlnK protein is a member of the trimeric PII signal transduction protein family. In nitrogen limitation it is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. In ammonium sufficient conditions non-uridylylated GlnK forms a 1:1 complex with the ammonia channel protein AmtB and prevents ammonium uptake through AmtB. Complex formation is reversed by ammonium starvation. [Comment provided by EcoTeam member Mike Merrick, 11.16.06][4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.