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References Suggestions


Standard Name


Gene Synonym(s)

yaeL, ECK0175, b0176, JW0171, ecf, ecfE[1][2][3], ecfE

Product Desc.

zinc metallopeptidase[3]; RseP zinc protease[2]

Inner membrane zinc RIP metalloprotease; activates RpoE by degrading RseA; multicopy rpoE suppresses rseP mutation[4]

Product Synonyms(s)

zinc metallopeptidase[1], B0176[3][1], EcfE[3][1], YaeL[3][1], RseP[3][1] , ecfE, ECK0175, JW0171, yaeL, b0176

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): yaeL[3]

Quick Links

porteco.png EcoCyc.gif regulondb.jpg

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RpoE regulon. RseP activates RpoE and releases membrane-bound RseA-RpoE complexes. Cleavage occurs around RseA membrane domain generating the N-terminal and the soluable product. rseP is an essential gene, but deletion of ompCF or ompCA (or an sRNA rseX clone, which suppresses ompCA translation) allows growth. RseP or some other protease degrades RseA in the released complexes. The RseA periplasmic domain must be first clipped or degraded by DegS before it is a substrate for RseP. RseP is related to the E. faecalis Eep protein involved in bacterial regulated intramembrane proteolysis (RIP). RseP has been topology mapped using protein fusions. RseP is reported to degrade RpoE and RpoH in vitro and to be an negative, not positive, effector of RpoE action in vivo, but the physiological relevance and/or accuracy of this has been strongly challenged.[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.