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References Suggestions


Standard Name


Gene Synonym(s)

ECK0160, b0161, JW0157, htrA, ptd[1], ptd

Product Desc.


Component of serine protease Do[3]

Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins[4]

Product Synonyms(s)

serine endoprotease (protease Do), membrane-associated[1], B0161[2][1], Ptd[2][1], protease Do[2][1], HtrA[2][1] , ECK0160, htrA, JW0157, ptd, b0161

Function from GO

<GO_nr />

Knock-Out Phenotype

transcription unit(s): degP[2], htrA

Quick Links

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Autocleavage occurs after Cys95(Cys69 of mature form) or Gln108 (Gln82 of mature form). Autocleavage causes hexameric DegP(HtrA) to dissociate into proteolytically active monomers. Targeted to some proteins by CpxP. Sigma E promoter. Mutants have elevated OM vesiculation (McBroom, 2006). DegP(HtrA) has chaperone activity (Skorko-Glonek, 2007).[4]


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  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.