fhuD:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
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Standard Name

fhuD

Gene Synonym(s)

ECK0151, b0152, JW0148[1], JW0148

Product Desc.

FhuD[2][3];

Component of iron (III) hydroxamate ABC transporter[2][3]; ferrichrome uptake system[3]

Iron-ferrichrome periplasmic binding protein; ferrichrome-dependent iron uptake; binds other hydroxamate siderophores; fhuD mutants are albomycin resistant[4]

Product Synonyms(s)

iron-hydroxamate transporter subunit[1], periplasmic-binding component of ABC superfamily[1], B0152[2][1], FhuD[2][1] , ECK0151, JW0148, b0152

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): fhuACDB[2], OP00027, fhuA

Regulation/Activity
Quick Links

porteco.png EcoCyc.gif regulondb.jpg

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Verified Tat substrate: FhuD has a predicted Tat-only (Class I) 30 aa signal peptide (Tullman-Ercek, 2007). The N-terminal sequence in Rohrback (1995), cited in Swiss-Prot, does not verify this putative SPI cleavage; it is the product of an enterokinase cleavage of a cloning construct. Rohrback (1995) demonstrated proper folding of FhuD in the cytoplasm prior to export, consistent with FhuD needing the Tat pathway, which exports folded proteins.[4]



References

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  1. 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.