Persister cells are bacterial cells that survive killing by antibiotics that block synthesis of peptidoglycan  or DNA , but remain sensitive to that antibiotic upon being regrown and give rise to the same small fraction of persisters. Persister cells were first described by Bigger in 1944  who found that there was always a small number of survivors (10-5 to 10-6) when cultures of Staphylococcus were treated with penicillin.
- Bigger, J.W. (1944) Treatment of staphylococcal infections with penicillin. Lancet ii:497-500. Cite error: Invalid
<ref>tag; name "BiggerJW1944" defined multiple times with different content
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