PMID:9973340
| Citation |
Hall, BG (1999) Spectra of spontaneous growth-dependent and adaptive mutations at ebgR. J. Bacteriol. 181:1149-55 |
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| Abstract |
A comparison of the spectra of spontaneous growth-dependent and adaptive mutations in ebgR shows that both spectra are dominated by insertion sequence (IS)-mediated mutations. The difference between growth-dependent mutations (61% IS mediated) and adaptive mutations (80% IS mediated) is highly significant (P < 0.0001). In contrast, the spectra of growth-dependent and adaptive non-IS-mediated mutations do not differ from each other and therefore do not provide support for the hypothesis that adaptive and growth-dependent mutations arise by substantially different mechanisms. |
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| Keywords |
Adaptation, Biological/genetics; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Models, Genetic; Mutagenesis/genetics; Mutagenesis, Insertional/genetics; Polymerase Chain Reaction; Repressor Proteins/genetics; Sequence Analysis, DNA; beta-Galactosidase/biosynthesis; beta-Galactosidase/genetics |
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