PMID:9891799
| Citation |
Hughes, KT and Mathee, K (1998) The anti-sigma factors. Annu. Rev. Microbiol. 52:231-86 |
|---|---|
| Abstract |
A mechanism for regulating gene expression at the level of transcription utilizes an antagonist of the sigma transcription factor known as the anti-sigma (anti-sigma) factor. The cytoplasmic class of anti-sigma factors has been well characterized. The class includes AsiA form bacteriophage T4, which inhibits Escherichia coli sigma 70; FlgM, present in both gram-positive and gram-negative bacteria, which inhibits the flagella sigma factor sigma 28; SpoIIAB, which inhibits the sporulation-specific sigma factor, sigma F and sigma G, of Bacillus subtilis; RbsW of B. subtilis, which inhibits stress response sigma factor sigma B; and DnaK, a general regulator of the heat shock response, which in bacteria inhibits the heat shock sigma factor sigma 32. In addition to this class of well-characterized cytoplasmic anti-sigma factors, a new class of homologous, inner-membrane-bound anti-sigma factors has recently been discovered in a variety of eubacteria. This new class of anti-sigma factors regulates the expression of so-called extracytoplasmic functions, and hence is known as the ECF subfamily of anti-sigma factors. The range of cell processes regulated by anti-sigma factors is highly varied and includes bacteriophage phage growth, sporulation, stress response, flagellar biosynthesis, pigment production, ion transport, and virulence. |
| Links |
PubMed Online version:10.1146/annurev.micro.52.1.231 |
| Keywords |
Bacterial Outer Membrane Proteins/pharmacology; Bacterial Proteins/pharmacology; Bacterial Proteins/physiology; Bacteriophage T4/chemistry; Carrier Proteins/pharmacology; Carrier Proteins/physiology; DNA-Binding Proteins/pharmacology; Escherichia coli/chemistry; Escherichia coli Proteins; Flagella/chemistry; HSP70 Heat-Shock Proteins/pharmacology; HSP70 Heat-Shock Proteins/physiology; Membrane Proteins/pharmacology; Membrane Transport Proteins; Myxococcus xanthus/chemistry; Photobacterium/chemistry; Pseudomonas aeruginosa/chemistry; Pseudomonas aeruginosa/pathogenicity; Salmonella/pathogenicity; Sigma Factor/antagonists & inhibitors; Sigma Factor/pharmacology; Sigma Factor/physiology; Spores, Bacterial/chemistry; Transcription Factors/pharmacology; Transcription Factors/physiology; Viral Proteins/pharmacology; Viral Proteins/physiology; Virulence |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.