PMID:9883723
| Citation |
Baloh, RH, Tansey, MG, Lampe, PA, Fahrner, TJ, Enomoto, H, Simburger, KS, Leitner, ML, Araki, T, Johnson, EM Jr and Milbrandt, J (1998) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron 21:1291-302 |
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| Abstract |
The glial cell line-derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a multicomponent receptor system composed of a high-affinity binding component (GFRalpha1-GFRalpha4) and a common signaling component (RET). Here, we report the identification of Artemin, a novel member of the GDNF family, and demonstrate that it is the ligand for the former orphan receptor GFRalpha3-RET. Artemin is a survival factor for sensory and sympathetic neurons in culture, and its expression pattern suggests that it also influences these neurons in vivo. Artemin can also activate the GFRalpha1-RET complex and supports the survival of dopaminergic midbrain neurons in culture, indicating that like GDNF (GFRalpha1-RET) and NTN (GFRalpha2-RET), Artemin has a preferred receptor (GFRalpha3-RET) but that alternative receptor interactions also occur. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Animals, Newborn; Binding Sites; Cell Survival; Cells, Cultured; Cloning, Molecular; Drosophila Proteins; Embryo, Mammalian; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Humans; Ligands; Mesencephalon/cytology; Mesencephalon/physiology; Mice; Models, Chemical; Molecular Sequence Data; Nerve Growth Factors/chemistry; Nerve Growth Factors/physiology; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/physiology; Neurons/cytology; Neurons/physiology; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-ret; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases/physiology; Recombinant Proteins/chemistry; Recombinant Proteins/metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction/physiology; Superior Cervical Ganglion/cytology; Superior Cervical Ganglion/physiology |
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